Accuracy of Pretransplant Imaging Diagnostic for Hepatocellular Carcinoma: A Retrospective German Multicenter Study
Joint Authors
Paul, Andreas
Stippel, Dirk
Lehner, Frank
Guba, Markus
Lorf, Thomas
Pratschke, Johann
Schmidt, Hartmut
Schöning, Wenzel
Herden, Uta
Linke, Richard
Braun, Felix
Sucher, Robert
Strassburg, Christian P.
van Rosmalen, Marieke
Rogiers, Xavier
Samuel, Undine
Schön, Gerhard MSc
Nashan, Bjoern
Manekeller, S.
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Selection and prioritization of patients with HCC for LT are based on pretransplant imaging diagnostic, taking the risk of incorrect diagnosis.
According to the German waitlist guidelines, imaging has to be reported to the allocation organization (Eurotransplant) and pathology reports have to be submitted thereafter.
In order to assess current procedures we performed a retrospective multicenter analysis in all German transplant centers with focus on accuracy of imaging diagnostic and tumor classification.
1168 primary LT for HCC were conducted between 2007 and 2013 in Germany.
Patients inside the Milan, UCSF, and up-to-seven criteria were misclassified with definitive histologic results in 18%, 15%, and 11%, respectively.
Patients pretransplant outside the Milan, UCSF, and up-to-seven criteria were otherwise misclassified in 34%, 43%, and 41%.
Recurrence-free survival correlated with classification by posttransplant histological report, but not pretransplant imaging diagnostic.
Univariate analysis revealed tumor size, vascular invasion, and grading as significant parameters for outcome, while tumor grading was the only parameter persisting by multivariate testing.
Conclusion.
There was a relevant percentage (15-40%) of patients misclassified by imaging diagnosis at a time prior to LI-RADS and guidelines to improve imaging of HCC.
Outcome analysis showed a good correlation to histological, in contrast poor correlation to imaging diagnosis, suggesting an adjustment of the LT selection and prioritization criteria.
American Psychological Association (APA)
Herden, Uta& Schöning, Wenzel& Pratschke, Johann& Manekeller, S.& Paul, Andreas& Linke, Richard…[et al.]. 2019. Accuracy of Pretransplant Imaging Diagnostic for Hepatocellular Carcinoma: A Retrospective German Multicenter Study. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1129931
Modern Language Association (MLA)
Herden, Uta…[et al.]. Accuracy of Pretransplant Imaging Diagnostic for Hepatocellular Carcinoma: A Retrospective German Multicenter Study. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1129931
American Medical Association (AMA)
Herden, Uta& Schöning, Wenzel& Pratschke, Johann& Manekeller, S.& Paul, Andreas& Linke, Richard…[et al.]. Accuracy of Pretransplant Imaging Diagnostic for Hepatocellular Carcinoma: A Retrospective German Multicenter Study. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1129931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129931