Prognostic Significance of Pretreatment NeutrophilLymphocyte Ratio and PlateletLymphocyte Ratio in Patients with Diffuse Large B-Cell Lymphoma
Joint Authors
Wang, Siqian
Ma, Yongyong
Sun, Lan
Shi, Yifen
Jiang, Songfu
Yu, Kang
Zhou, Shujuan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
It is generally believed that there is correlation between cancer prognosis and pretreatment PLR and NLR.
However, there are limited data about their role in diffuse large B cell lymphoma (DLBCL).
This study aims to determine the prognostic value of pretreatment PLR and NLR for patients who have DLBCL.
The associations between clinical characteristics and NLR and PLR were evaluated among 182 DLBCL patients from January 2005 to June 2016.
The optimal cutoff values for high PLR (⩾150) and NLR (⩾2.32) in prognosis prediction were determined.
The effect of NLR and PLR on survival was evaluated through multivariate Cox regression analysis, univariate analysis, and log-rank test.
According to the evaluation results, patients with high NLR and PLR had significantly shorter OS (P=0.026 and P=0.035) and PFS (P=0.024 and P=0.022) compared with those who have low PLR and NLR.
On multivariate analyses, IPI>2, elevated LDH, and PLR⩾2.32 were prognostic factors for OS and PFS in DLBCL patients.
Therefore, we demonstrated that high PLR and NLR predicted adverse prognostic factors in DLBCL patients.
American Psychological Association (APA)
Wang, Siqian& Ma, Yongyong& Sun, Lan& Shi, Yifen& Jiang, Songfu& Yu, Kang…[et al.]. 2018. Prognostic Significance of Pretreatment NeutrophilLymphocyte Ratio and PlateletLymphocyte Ratio in Patients with Diffuse Large B-Cell Lymphoma. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129945
Modern Language Association (MLA)
Wang, Siqian…[et al.]. Prognostic Significance of Pretreatment NeutrophilLymphocyte Ratio and PlateletLymphocyte Ratio in Patients with Diffuse Large B-Cell Lymphoma. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1129945
American Medical Association (AMA)
Wang, Siqian& Ma, Yongyong& Sun, Lan& Shi, Yifen& Jiang, Songfu& Yu, Kang…[et al.]. Prognostic Significance of Pretreatment NeutrophilLymphocyte Ratio and PlateletLymphocyte Ratio in Patients with Diffuse Large B-Cell Lymphoma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1129945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129945