Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma
Joint Authors
Yang, Taewoo
Choi, Yegyun
Joh, Jae Won
Cho, Steve K.
Kim, Dae-Shick
Park, Sung-Gyoo
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a poor prognosis.
Several commonly investigated immunohistochemical markers in resected HCC have potential prognostic value, but the prognostic utility of p53 expression in HCC has remained elusive.
Aim.
To evaluate the prognostic value of p53 and p53 phosphorylation at serine 15 (p53 Ser15-P) in patients with HCC.
Methods.
Surgically resected tumors from 199 HCC patients were analyzed for p21, p53, p53 Ser15-P, and proliferating cell nuclear antigen (PCNA) expression using immunohistochemistry.
Results.
Stratifying by the expression of p53 Ser15-P (P = 0.016), but not by p53 (P = 0.301), revealed significantly different survival outcomes in patients with HCC.
Moreover, our analysis demonstrated that patients who were PCNA-positive and p53 Ser15-P–negative had significantly worse survival outcomes (P = 0.001) than patients who were PCNA-positive and p53 Ser15-P–positive.
Conclusions.
P53 Ser15-P is associated with poor outcomes in patients with HCC, and this prognostic marker is useful for predicting the survival of patients with PCNA-positive HCC.
American Psychological Association (APA)
Yang, Taewoo& Choi, Yegyun& Joh, Jae Won& Cho, Steve K.& Kim, Dae-Shick& Park, Sung-Gyoo. 2019. Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1129946
Modern Language Association (MLA)
Yang, Taewoo…[et al.]. Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1129946
American Medical Association (AMA)
Yang, Taewoo& Choi, Yegyun& Joh, Jae Won& Cho, Steve K.& Kim, Dae-Shick& Park, Sung-Gyoo. Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1129946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129946