The Differential Expression of Core Genes in Nucleotide Excision Repair Pathway Indicates Colorectal Carcinogenesis and Prognosis
Joint Authors
Wang, Zhen-ning
Yuan, Yuan
Liu, Jingwei
Li, Hao
Sun, Liping
Feng, Xue
Xing, Chengzhong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Nucleotide excision repair (NER) plays a critical role in maintaining genome integrity.
This study aimed to investigate the expression of NER genes and their associations with colorectal cancer (CRC) development.
Method.
Expressions of NER genes in CRC and normal tissues were analysed by ONCOMINE.
The Cancer Genome Atlas (TCGA) data were downloaded to explore relationship of NER expression with clinicopathological parameters and survival of CRC.
Results.
ERCC1, ERCC2, ERCC5, and DDB2 were upregulated while ERCC4 was downregulated in CRC.
For colon cancer, high ERCC3 expression was related to better T stage; ERCC5 expression indicated deeper T stage and distant metastasis; DDB2 expression suggested earlier TNM stage.
For rectal cancer, ERCC2 expression correlated with favourable T stage; XPA expression predicted worse TNM stage.
ERCC2 expression was associated with worse overall survival (OS) in colon cancer (HR=1.53, P=0.043).
Colon cancer patients with high ERCC4 expression showed favorable OS in males (HR=0.54, P=0.035).
High XPC expression demonstrated decreased death hazards in rectal cancer (HR=0.40, P=0.026).
Conclusion.
ERCC1, ERCC2, ERCC4, ERCC5, and DDB2 were differently expressed in CRC and normal tissues; ERCC2, ERCC3, ERCC5, XPA, and DDB2 correlated with clinicopathological parameters of CRC, while ERCC2, ERCC4, and XPC might predict CRC prognosis.
American Psychological Association (APA)
Liu, Jingwei& Li, Hao& Sun, Liping& Feng, Xue& Wang, Zhen-ning& Yuan, Yuan…[et al.]. 2018. The Differential Expression of Core Genes in Nucleotide Excision Repair Pathway Indicates Colorectal Carcinogenesis and Prognosis. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129948
Modern Language Association (MLA)
Liu, Jingwei…[et al.]. The Differential Expression of Core Genes in Nucleotide Excision Repair Pathway Indicates Colorectal Carcinogenesis and Prognosis. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1129948
American Medical Association (AMA)
Liu, Jingwei& Li, Hao& Sun, Liping& Feng, Xue& Wang, Zhen-ning& Yuan, Yuan…[et al.]. The Differential Expression of Core Genes in Nucleotide Excision Repair Pathway Indicates Colorectal Carcinogenesis and Prognosis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1129948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129948