Copper Mediates Anti-Inflammatory and Antifibrotic Activity of Gleevec in Hepatocellular Carcinoma-Induced Male Rats
Joint Authors
Hassan, Iftekhar
Alhazza, Ibrahim
Ebaid, Hossam
Al-Tamimi, Jameel
Aman, Shazia
Abdel-Mageed, Ahmad M.
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The elevated level of copper is one of the hallmark features of cancer cells in most of the types of cancer.
In the present study, this feature has been targeted to investigate if coadministration of exogenous copper (Cu+) and its chelating agent like disulfiram (DSF+) influence the antineoplastic activity of the anticancer drug, Gleevec (GLV+), in hepatocellular carcinoma (HCC)-induced rats via immunomodulation.
After the treatment, the level of proinflammatory interleukins (IL-1, 2, 6, and 7), anti-inflammatory interleukin (IL-10) concomitant with transcription factors (NF-kB and TNF-a), and the apoptotic marker (cleaved PARP) was estimated.
The cancer-induced group without treatment (CN+) demonstrated abnormally elevated level of all proinflammatory cytokines and transcription factors concomitant with a compromised level of cleaved PARP as compared to the control normal (CN-).
The detailed histological analysis also supported the results exhibiting extensive inflammation and tissue fibrosis confirming the second stage of HCC.
Cu+, DSF+, and GLV+ displayed mild improvement in most of the parameters, but the combination group GLV + Cu+ demonstrated remarkable recovery in histology and most of the parameters tended towards the CN- followed by GLV + DSF+.
Therefore, the management of copper level is critical in realizing the antineoplastic activity of GLV up to its full potential in cancer treatment.
These findings will help in improving chemoimmunotherapy and personalized cancer treatment.
American Psychological Association (APA)
Hassan, Iftekhar& Ebaid, Hossam& Alhazza, Ibrahim& Al-Tamimi, Jameel& Aman, Shazia& Abdel-Mageed, Ahmad M.. 2019. Copper Mediates Anti-Inflammatory and Antifibrotic Activity of Gleevec in Hepatocellular Carcinoma-Induced Male Rats. Canadian Journal of Gastroenterology and Hepatology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1129974
Modern Language Association (MLA)
Hassan, Iftekhar…[et al.]. Copper Mediates Anti-Inflammatory and Antifibrotic Activity of Gleevec in Hepatocellular Carcinoma-Induced Male Rats. Canadian Journal of Gastroenterology and Hepatology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1129974
American Medical Association (AMA)
Hassan, Iftekhar& Ebaid, Hossam& Alhazza, Ibrahim& Al-Tamimi, Jameel& Aman, Shazia& Abdel-Mageed, Ahmad M.. Copper Mediates Anti-Inflammatory and Antifibrotic Activity of Gleevec in Hepatocellular Carcinoma-Induced Male Rats. Canadian Journal of Gastroenterology and Hepatology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1129974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129974