Evolution of Therapeutic Antibodies, Influenza Virus Biology, Influenza, and Influenza Immunotherapy
Joint Authors
Chaisri, Urai
Chaicumpa, Wanpen
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-28
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
This narrative review article summarizes past and current technologies for generating antibodies for passive immunization/immunotherapy.
Contemporary DNA and protein technologies have facilitated the development of engineered therapeutic monoclonal antibodies in a variety of formats according to the required effector functions.
Chimeric, humanized, and human monoclonal antibodies to antigenic/epitopic myriads with less immunogenicity than animal-derived antibodies in human recipients can be produced in vitro.
Immunotherapy with ready-to-use antibodies has gained wide acceptance as a powerful treatment against both infectious and noninfectious diseases.
Influenza, a highly contagious disease, precipitates annual epidemics and occasional pandemics, resulting in high health and economic burden worldwide.
Currently available drugs are becoming less and less effective against this rapidly mutating virus.
Alternative treatment strategies are needed, particularly for individuals at high risk for severe morbidity.
In a setting where vaccines are not yet protective or available, human antibodies that are broadly effective against various influenza subtypes could be highly efficacious in lowering morbidity and mortality and controlling unprecedented epidemic/pandemic.
Prototypes of human single-chain antibodies to several conserved proteins of influenza virus with no Fc portion (hence, no ADE effect in recipients) are available.
These antibodies have high potential as a novel, safe, and effective anti-influenza agent.
American Psychological Association (APA)
Chaisri, Urai& Chaicumpa, Wanpen. 2018. Evolution of Therapeutic Antibodies, Influenza Virus Biology, Influenza, and Influenza Immunotherapy. BioMed Research International،Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1129997
Modern Language Association (MLA)
Chaisri, Urai& Chaicumpa, Wanpen. Evolution of Therapeutic Antibodies, Influenza Virus Biology, Influenza, and Influenza Immunotherapy. BioMed Research International No. 2018 (2018), pp.1-23.
https://search.emarefa.net/detail/BIM-1129997
American Medical Association (AMA)
Chaisri, Urai& Chaicumpa, Wanpen. Evolution of Therapeutic Antibodies, Influenza Virus Biology, Influenza, and Influenza Immunotherapy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1129997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129997