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Development of Nanoemulsions to Enhance the Antileishmanial Activity of Copaifera paupera Oleoresins
Joint Authors
Rodrigues, Igor A.
Ramos, Aline de S.
Amaral, Ana Cláudia Fernandes
Falcão, Deborah Q.
Ferreira, José Luiz P.
Basso, Silvia L.
Silva, Jefferson Rocha de A.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Based on the ethnopharmacological evidences about the antileishmanial activity of Copaifera spp.
oleoresins, the effects of crude extracts and fractions of oleoresin of two specimens from Copaifera paupera were evaluated on Leishmania amazonensis and Leishmania infantum strains.
The oleoresin rich in α-copaene (38.8%) exhibited the best activity against L.
amazonensis (IC50 = 62.5 μg/mL) and against L.
infantum (IC50 = 65.9 μg/mL).
The sesquiterpene α-copaene isolated was tested alone and exhibited high antileishmanial activity in vitro with IC50 values for L.
amazonensis and L.
infantum of 17.2 and 11.4 μg/mL, respectively.
In order to increase antileishmanial activity, nanoemulsions containing copaiba oleoresin and α-copaene were developed and assayed against L.
amazonensis and L.
infantum promastigotes.
The nanoemulsion containing α-copaene (NANOCOPAEN) showed the best activity against both species, with IC50 of 2.5 and 2.2 μg/mL, respectively.
This is the first report about the antileishmanial activity of α-copaene.
American Psychological Association (APA)
Rodrigues, Igor A.& Ramos, Aline de S.& Falcão, Deborah Q.& Ferreira, José Luiz P.& Basso, Silvia L.& Silva, Jefferson Rocha de A.…[et al.]. 2018. Development of Nanoemulsions to Enhance the Antileishmanial Activity of Copaifera paupera Oleoresins. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130016
Modern Language Association (MLA)
Rodrigues, Igor A.…[et al.]. Development of Nanoemulsions to Enhance the Antileishmanial Activity of Copaifera paupera Oleoresins. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1130016
American Medical Association (AMA)
Rodrigues, Igor A.& Ramos, Aline de S.& Falcão, Deborah Q.& Ferreira, José Luiz P.& Basso, Silvia L.& Silva, Jefferson Rocha de A.…[et al.]. Development of Nanoemulsions to Enhance the Antileishmanial Activity of Copaifera paupera Oleoresins. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130016