Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer
Joint Authors
Xu, Ji-Xiong
Liu, Ying
Cui, Jian
Tang, Yun-Liang
Huang, Liang
Zhou, Cong-Yang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The S100 protein family is involved in cancer cell invasion and metastasis, but its prognostic value in non-small-cell lung cancer (NSCLC) has not been elucidated.
In the present study we investigated the prognostic role of mRNA expression of each individual S100 in NSCLC patients through the Kaplan–Meier plotter (KM plotter) database.
Expression of 14 members of the S100 family correlated with overall survival (OS) for all NSCLC patients; 18 members were associated with OS in adenocarcinoma, but none were associated with OS in squamous cell carcinoma.
In particular, high mRNA expression level of S100B was associated with better OS in NSCLC patients.
The prognostic value of S100 according to smoking status, pathological grades, clinical stages, and chemotherapeutic treatment of NSCLC was further assessed.
Although the results should be further verified in clinical trials our findings provide new insights into the prognostic roles of S100 proteins in NSCLC and might promote development of S100-targeted inhibitors for the treatment of NSCLC.
American Psychological Association (APA)
Liu, Ying& Cui, Jian& Tang, Yun-Liang& Huang, Liang& Zhou, Cong-Yang& Xu, Ji-Xiong. 2018. Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1130057
Modern Language Association (MLA)
Liu, Ying…[et al.]. Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1130057
American Medical Association (AMA)
Liu, Ying& Cui, Jian& Tang, Yun-Liang& Huang, Liang& Zhou, Cong-Yang& Xu, Ji-Xiong. Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1130057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130057