An Overview of Meta-Analyses of Endovascular Bridging Therapies for Acute Ischemic Stroke
Joint Authors
Chen, Si-Yan
Zhang, Xing-Ru
Chen, Jie
Ge, Wan-Qian
Wang, Wen-Wen
Wang, Xin-Shi
Xie, Cheng-Long
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Acute Ischemic Stroke (AIS) is a common cause of death worldwide and the leading cause of long-term severe disability.
Endovascular bridging therapies (EBT), including endovascular thrombectomy (ET) and intra-arterial thrombolytic (IAT), have been recommended to realize a favorable functional outcome for AIS patients.
Methods.
An overview of meta-analyses of primary randomized controlled trial (RCT) studies was performed evaluating EBT for AIS patients compared with usual care.
Results.
Ten meta-analyses were included in this overview.
ET was associated with a higher incidence of achieving functional outcome improvement, defined as a modified Rankin scale of 0 to 1 (mRS, p=0.003), 0 to 2 (p<0.00001), and 0 to 3 (p=0.005).
The risk of symptomatic intracranial hemorrhage (sICH) rate and all-cause mortality were similar between the two groups.
Moreover, IAT treatment was also related to significantly improved outcomes in terms of the mRS score (p<0.05), but no significant difference in rates of sICH and mortality within 90 days.
Conclusions.
In conclusion, our analysis supports that EBT, regardless of format (e.g., ET or IAT), is superior to the best medical therapy alone (e.g., IVT) in terms of mRS score in patients with AIS.
In addition, the safety of EBT is similar to IVT.
American Psychological Association (APA)
Chen, Si-Yan& Zhang, Xing-Ru& Chen, Jie& Ge, Wan-Qian& Wang, Wen-Wen& Wang, Xin-Shi…[et al.]. 2018. An Overview of Meta-Analyses of Endovascular Bridging Therapies for Acute Ischemic Stroke. BioMed Research International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1130066
Modern Language Association (MLA)
Chen, Si-Yan…[et al.]. An Overview of Meta-Analyses of Endovascular Bridging Therapies for Acute Ischemic Stroke. BioMed Research International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1130066
American Medical Association (AMA)
Chen, Si-Yan& Zhang, Xing-Ru& Chen, Jie& Ge, Wan-Qian& Wang, Wen-Wen& Wang, Xin-Shi…[et al.]. An Overview of Meta-Analyses of Endovascular Bridging Therapies for Acute Ischemic Stroke. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1130066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130066