Thyroid Autoimmunity and Autoimmunity in Chronic Spontaneous Urticaria Linked to Disease Severity, Therapeutic Response, and Time to Remission in Patients with Chronic Spontaneous Urticaria
Joint Authors
Iamsumang, Wimolsiri
Chanprapaph, Kumutnart
Vachiramon, Vasanop
Wattanakrai, Penpun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Chronic spontaneous urticaria (CSU) is autoimmune in nature and associated with thyroid autoimmunity (TA), but evidence on autoimmunity in relation to CSU progression and prognosis is limited.
We evaluated whether TA and autoimmunity in CSU are correlated with disease severity, therapeutic response, and time to remission and establish an association between CSU characteristics linked to thyroid autoantibody.
Methods.
Medical records of patients diagnosed with urticaria attending outpatient dermatology clinic at a university-based hospital from 2013 to 2017 were retrospectively reviewed.
Data on the clinical characteristics, laboratory investigations particularly thyroid antibody titers, autologous serum skin test (ASST) and autologous plasma skin test (APST) results and their link to disease severity, treatments, and time to remission of CSU patients were analyzed.
Results.
Of 1,096 patients with urticaria, 60.2% had CSU.
Three-hundred patients fulfilled the inclusion criteria for CSU with complete thyroid antibody testing.
Positive TA was significantly associated with female gender and age > 35 years (p = 0.008).
Antithyroid peroxidase (anti-TPO)-positive patients suffered from CSU longer than 12 and 18 months compared to anti-TPO-negative patients (100.0% vs.
82.6%, p = 0.042, and 100.0% vs.
75.9% p = 0.020, respectively).
The presence of urticarial attacks > 4 days/week was significantly seen in ASST and APST-positive patients compared to those without (84.6% vs.
61.3%, p = 0.011, and 85.3% vs.
61.8%, p = 0.006, respectively).
Positive APST patients were more difficult to treat than those with negative results (61.2% vs.
37.8%, p = 0.017).
Conclusions.
Antithyroid peroxidase is a predictor of time to remission, while autologous skin testing is linked to disease severity (ASST and APST) and therapeutic response (APST) in CSU patients.
American Psychological Association (APA)
Chanprapaph, Kumutnart& Iamsumang, Wimolsiri& Wattanakrai, Penpun& Vachiramon, Vasanop. 2018. Thyroid Autoimmunity and Autoimmunity in Chronic Spontaneous Urticaria Linked to Disease Severity, Therapeutic Response, and Time to Remission in Patients with Chronic Spontaneous Urticaria. BioMed Research International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1130104
Modern Language Association (MLA)
Chanprapaph, Kumutnart…[et al.]. Thyroid Autoimmunity and Autoimmunity in Chronic Spontaneous Urticaria Linked to Disease Severity, Therapeutic Response, and Time to Remission in Patients with Chronic Spontaneous Urticaria. BioMed Research International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1130104
American Medical Association (AMA)
Chanprapaph, Kumutnart& Iamsumang, Wimolsiri& Wattanakrai, Penpun& Vachiramon, Vasanop. Thyroid Autoimmunity and Autoimmunity in Chronic Spontaneous Urticaria Linked to Disease Severity, Therapeutic Response, and Time to Remission in Patients with Chronic Spontaneous Urticaria. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1130104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130104