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Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives
Joint Authors
Wijerathna, Tharaka
Perera, Hirunika
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cholesterol is one of the most vital compounds for animals as it is involved in various biological processes and acts as the structural material in the body.
However, insects do not have some of the essential enzymes in the cholesterol biosynthesis pathway and this makes them dependent on dietary cholesterol.
Thus, the blocking of cholesterol uptake may have detrimental effects on the survival of the insect.
Utilizing this character, certain phytochemicals can be used to inhibit mosquito sterol carrier protein-2 (AeSCP-2) activity via competitive binding and proven to have effective insecticidal activities against disease-transmitting mosquitoes and other insect vectors.
A range of synthetic compounds, phytochemicals, and synthetic analogs of phytochemicals are found to have AeSCP-2 inhibitory activity.
Phytochemicals such as alpha-mangostin can be considered as the most promising group of compounds when considering the minimum environmental impact and availability at a low cost.
Once the few limitations such as very low persistence in the environment are addressed successfully, these chemicals may be used as an effective tool for controlling mosquitoes and other disease-transmitting vector populations.
American Psychological Association (APA)
Perera, Hirunika& Wijerathna, Tharaka. 2019. Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1130106
Modern Language Association (MLA)
Perera, Hirunika& Wijerathna, Tharaka. Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1130106
American Medical Association (AMA)
Perera, Hirunika& Wijerathna, Tharaka. Sterol Carrier Protein Inhibition-Based Control of Mosquito Vectors: Current Knowledge and Future Perspectives. Canadian Journal of Infectious Diseases and Medical Microbiology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1130106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130106