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Dynamic Expression of Genes Involved in ProteoglycanGlycosaminoglycan Metabolism during Skin Development
Joint Authors
Daamen, Willeke F.
Uijtdewilligen, P. J. E.
Versteeg, E. M.
Westerlo, E. M. A. van de
Vlag, J. van der
Kuppevelt, T. H. van
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-29
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Glycosaminoglycans are important for cell signaling and therefore for proper embryonic development and adult homeostasis.
Expressions of genes involved in proteoglycan/glycosaminoglycan (GAG) metabolism and of genes coding for growth factors known to bind GAGs were analyzed during skin development by microarray analysis and real time quantitative PCR.
GAG related genes were organized in six categories based on their role in GAG homeostasis, viz.
(1) production of precursor molecules, (2) production of core proteins, (3) synthesis of the linkage region, (4) polymerization, (5) modification, and (6) degradation of the GAG chain.
In all categories highly dynamic up- and downregulations were observed during skin development, including differential expression of GAG modifying isoenzymes, core proteins, and growth factors.
In two mice models, one overexpressing heparanase and one lacking C5 epimerase, differential expression of only few genes was observed.
Data show that during skin development a highly dynamic and complex expression of GAG-associated genes occurs.
This likely reflects quantitative and qualitative changes in GAGs/proteoglycans, including structural fine tuning, which may be correlated with growth factor handling.
American Psychological Association (APA)
Uijtdewilligen, P. J. E.& Versteeg, E. M.& Westerlo, E. M. A. van de& Vlag, J. van der& Daamen, Willeke F.& Kuppevelt, T. H. van. 2018. Dynamic Expression of Genes Involved in ProteoglycanGlycosaminoglycan Metabolism during Skin Development. BioMed Research International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1130138
Modern Language Association (MLA)
Uijtdewilligen, P. J. E.…[et al.]. Dynamic Expression of Genes Involved in ProteoglycanGlycosaminoglycan Metabolism during Skin Development. BioMed Research International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1130138
American Medical Association (AMA)
Uijtdewilligen, P. J. E.& Versteeg, E. M.& Westerlo, E. M. A. van de& Vlag, J. van der& Daamen, Willeke F.& Kuppevelt, T. H. van. Dynamic Expression of Genes Involved in ProteoglycanGlycosaminoglycan Metabolism during Skin Development. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1130138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130138