Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALBc Mice
Joint Authors
Gadaga, Louis L.
Tagwireyi, Dexter
Jilani, Mohammed S.
Mutsimhu, Cosmas
Maponga, Charles Chiedza
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Crinum macowanii is a bulbous plant indigenous to many parts of Southern Africa.
Extracts of C.
macowanii have gained interest since the discovery of various alkaloids, few of which possess acetylcholinesterase inhibitory activity.
The present study was performed to evaluate the effect of a crude hydroethanolic extract of C.
macowanii against aluminum chloride-induced memory impairment in mice using the Morris water maze and the novel object recognition task.
C.
macowanii (10, 20, and 40 mg/kg p.o) was administered daily for five weeks, while donepezil (3 mg/kg p.o) was used as the positive control.
C.
macowanii at a dosage of 40 mg/kg showed a significantly lower escape latency than the negative control (P<0.0001) and was found to be comparable to donepezil 3 mg/kg in the Morris water maze test.
C.
macowanii at 40 mg/kg exhibited a significantly higher discrimination index than aluminum chloride-treated mice in the novel object recognition task.
The results may support the usefulness of C.
macowanii in the management of dementia and related illnesses.
American Psychological Association (APA)
Jilani, Mohammed S.& Tagwireyi, Dexter& Gadaga, Louis L.& Maponga, Charles Chiedza& Mutsimhu, Cosmas. 2018. Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALBc Mice. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130159
Modern Language Association (MLA)
Jilani, Mohammed S.…[et al.]. Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALBc Mice. Behavioural Neurology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1130159
American Medical Association (AMA)
Jilani, Mohammed S.& Tagwireyi, Dexter& Gadaga, Louis L.& Maponga, Charles Chiedza& Mutsimhu, Cosmas. Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALBc Mice. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130159