Dynamic Contrast-Enhanced MR with Quantitative Perfusion Analysis of Small Bowel in Vascular Assessment between Inflammatory and Fibrotic Lesions in Crohnʼs Disease: A Feasibility Study
Joint Authors
Ippolito, Davide
Querques, Giulia
Drago, Silvia Girolama
Sironi, Sandro
Talei Franzesi, Cammillo
Lombardi, Sophie
Casiraghi, Alessandra
Pecorelli, Anna
Riva, Luca
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Aim.
To assess the feasibility of dynamic contrast-enhanced perfusion-MRI in characterization of active small-bowel inflammation and chronic mural fibrosis in patients with Crohnʼs disease (CD).
Methods.
We analyzed a total of 37 (11 women; 23–69 years) patients with known biopsy proven CD, who underwent MR-enterography (MRE) study, performed on a 1.5 T MRI system (Achieva, Philips), using a phased array sense body multicoil, after oral administration of 1.5–2 L of PEG solution.
MRE protocol included T1 weighted, SSh T2, sBTFE, and gadolinium-enhanced THRIVE sequences acquired on coronal and axial planes.
A dedicated workstation was used to generate perfusion color maps, on which we drown ROI on normal bowel and on pathological segment, thus obtaining related perfusion parameters: relative arterial, venous, and late enhancement (RAE, RVE, and RLE), maximum enhancement (ME), and time to peak (TTP).
Results.
Quantitative perfusion analysis showed a good correlation with local degree of Crohn’s inflammation activity.
Twenty-nine out of 37 patients showed active inflammatory disease (reference standard of active disease: wall bowel thickness and layered enhancement) with following perfusion parameters: REA (%) = 116.1, RVE (%) = 125.3, RLE (%) = 127.1, ME (%) = 1054.7, TTP (sec) = 157.
The same parameters calculated in patients with mural fibrosis were as follows: RAE (%): median = 56.4; RVE (%): 81.2; RLE (%): 85.4; ME (%):809.6; TTP (sec): 203.4.
A significant difference (p<0.001) between inflamed and fibrotic bowel wall vascularity, regarding all perfusion parameters evaluated, was found, with higher values in active CD localizations.
Conclusion.
Vascular assessment of perfusion kinetics of bowel wall by dynamic contrast perfusion-MR analysis may represent a complementary diagnostic tool that enables a quantitative evaluation of local inflammation activity in CD patients.
American Psychological Association (APA)
Ippolito, Davide& Lombardi, Sophie& Talei Franzesi, Cammillo& Drago, Silvia Girolama& Querques, Giulia& Casiraghi, Alessandra…[et al.]. 2019. Dynamic Contrast-Enhanced MR with Quantitative Perfusion Analysis of Small Bowel in Vascular Assessment between Inflammatory and Fibrotic Lesions in Crohnʼs Disease: A Feasibility Study. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130163
Modern Language Association (MLA)
Ippolito, Davide…[et al.]. Dynamic Contrast-Enhanced MR with Quantitative Perfusion Analysis of Small Bowel in Vascular Assessment between Inflammatory and Fibrotic Lesions in Crohnʼs Disease: A Feasibility Study. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1130163
American Medical Association (AMA)
Ippolito, Davide& Lombardi, Sophie& Talei Franzesi, Cammillo& Drago, Silvia Girolama& Querques, Giulia& Casiraghi, Alessandra…[et al.]. Dynamic Contrast-Enhanced MR with Quantitative Perfusion Analysis of Small Bowel in Vascular Assessment between Inflammatory and Fibrotic Lesions in Crohnʼs Disease: A Feasibility Study. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130163