Diffusion Kurtosis MR Imaging versus Conventional Diffusion-Weighted Imaging for Distinguishing Hepatocellular Carcinoma from Benign Hepatic Nodules
Joint Authors
Yan, Xu
Feng, Shi-Ting
Jia, Yingmei
Cai, Huasong
Wang, Meng
Luo, Yanji
Xu, Ling
Dong, Zhi
Li, Zi-Ping
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
To assess the efficacy of diffusion kurtosis imaging (DKI) and compare DKI-derived parameters with conventional diffusion-weighted imaging (DWI) for distinguishing hepatocellular carcinoma (HCC) from benign hepatic nodules including focal nodular hyperplasia (FNH), hemangioma, and hepatocellular adenoma (HCA).
Materials and Methods.
151 patients with 182 hepatic nodules (114 HCCs and 68 benign nodules including 33 FNHs, 29 hemangiomas, and 6 HCAs) were analyzed.
Preoperative MRI examinations including DKI (b values: 0, 200, 500, 800, 1500, and 2000 sec/mm2) were performed, and kurtosis (K), diffusivity (D), and apparent diffusion coefficient (ADC) were calculated.
The efficacy of DKI-derived parameters K, D, and ADC for distinguishing HCC from these benign nodules was analyzed.
Results.
ROC (receiver operating characteristic curve) analysis showed the optimal cutoff values of ADC, D, and K for identification of these benign nodules, and HCCs were 1.295 (area under the curve (AUC): 0.826; sensitivity 80.6%; specificity 70.8%), 1.787 (AUC: 0.770; sensitivity 83.6%; specificity 59.6%), and 1.002 (AUC: 0.761; sensitivity 65.5%; specificity 79.0%), respectively.
Statistically significant differences were found in ADC, D, and K values between groups of HCC-FNH and HCC-hemangioma (P<0.05).
There were significant differences in K and ADC values between groups of FNH-hemangioma and HCA-hemangioma (P<0.05), respectively.
Using logistic regression analysis, a regression equation was obtained: LogitP=−1.982X1+1.385X3+1.948(X1: ADC; X3: K), and odds ratios (OR) were 0.138 (95% confidence interval (CI): 0.052, 0.367), and 8.996 (95% CI: 0.970, 16.460), respectively.
Conclusion.
Both ADC value and DKI-derived parameters K and D values have demonstrated a higher preoperative efficacy in distinguishing HCC from FNH, hemangioma, and HCA.
No evidence was shown to suggest D or K value was superior to the ADC value.
American Psychological Association (APA)
Jia, Yingmei& Cai, Huasong& Wang, Meng& Luo, Yanji& Xu, Ling& Dong, Zhi…[et al.]. 2019. Diffusion Kurtosis MR Imaging versus Conventional Diffusion-Weighted Imaging for Distinguishing Hepatocellular Carcinoma from Benign Hepatic Nodules. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130171
Modern Language Association (MLA)
Jia, Yingmei…[et al.]. Diffusion Kurtosis MR Imaging versus Conventional Diffusion-Weighted Imaging for Distinguishing Hepatocellular Carcinoma from Benign Hepatic Nodules. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1130171
American Medical Association (AMA)
Jia, Yingmei& Cai, Huasong& Wang, Meng& Luo, Yanji& Xu, Ling& Dong, Zhi…[et al.]. Diffusion Kurtosis MR Imaging versus Conventional Diffusion-Weighted Imaging for Distinguishing Hepatocellular Carcinoma from Benign Hepatic Nodules. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130171