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Monitoring the Early Response of Fulvestrant Plus Tanshinone IIA Combination Therapy to Estrogen Receptor-Positive Breast Cancer by Longitudinal 18F-FES PETCT
Joint Authors
He, SiMin
Zhang, YongPing
Luo, JianMin
Zhang, YingJian
Wang, Ming-Wei
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Endocrine monotherapy of breast cancers is generally hampered by the primary/acquired resistance and adverse sides in clinical settings.
Herein, advantaging the multitargeting antitumor effects and normal organ-protecting roles of Chinese herbal medicine, the aim of this study was to investigate the enhanced synergistic efficacy of fulvestrant plus Tan IIA combination therapy in ER-positive breast cancers and to monitor the early response by longitudinal 18F-FES PET/CT imaging.
The experimental results showed FUL + Tan IIA combination therapy significantly inhibited tumor growth of ER-positive ZR-75-1 tumor xenografts and exhibited distinct antitumor effects at an earlier time point after treatment than did the monotherapy of FUL or Tan IIA.
Moreover, 18F-FES PET/CT imaging competently monitored the early response of FUL + Tan IIA combination therapy.
The quantitative 18F-FES %ID/gmax in vivo was further confirmed by and correlated well with ERα expression ex vivo.
In conclusion, the synergic effect of FUL + Tan IIA combination therapy to ER-positive breast cancers was verified in the preclinical tumor models and the early treatment response could be monitored by 18F-FES PET/CT.
American Psychological Association (APA)
He, SiMin& Wang, Ming-Wei& Zhang, YongPing& Luo, JianMin& Zhang, YingJian. 2019. Monitoring the Early Response of Fulvestrant Plus Tanshinone IIA Combination Therapy to Estrogen Receptor-Positive Breast Cancer by Longitudinal 18F-FES PETCT. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1130179
Modern Language Association (MLA)
He, SiMin…[et al.]. Monitoring the Early Response of Fulvestrant Plus Tanshinone IIA Combination Therapy to Estrogen Receptor-Positive Breast Cancer by Longitudinal 18F-FES PETCT. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1130179
American Medical Association (AMA)
He, SiMin& Wang, Ming-Wei& Zhang, YongPing& Luo, JianMin& Zhang, YingJian. Monitoring the Early Response of Fulvestrant Plus Tanshinone IIA Combination Therapy to Estrogen Receptor-Positive Breast Cancer by Longitudinal 18F-FES PETCT. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1130179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130179