Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies
Joint Authors
Tsai, Nu-Man
Ho, Ying-Jui
Weng, Jun-Cheng
Lin, Chih-Li
Shen, Mei-Shiuan
Li, Hsin-Hua
Liao, Wen-Chieh
Hung, Ching-Sui
Lai, Te-Jen
Lee, I-Yen
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α-synuclein inclusions in the brain.
Ceftriaxone (CEF), a β-lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block α-synuclein polymerization.
By using manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemistry, we measured the effects of CEF on neuronal activity and α-synuclein accumulation in the brain in a DLB rat model.
The data showed that CEF corrected neuronal density and activity in the hippocampal CA1 area, suppressed hyperactivity in the subthalamic nucleus, and reduced α-synuclein accumulation, indicating that CEF is a potential agent in the treatment of DLB.
American Psychological Association (APA)
Ho, Ying-Jui& Weng, Jun-Cheng& Lin, Chih-Li& Shen, Mei-Shiuan& Li, Hsin-Hua& Liao, Wen-Chieh…[et al.]. 2018. Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130198
Modern Language Association (MLA)
Ho, Ying-Jui…[et al.]. Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies. Behavioural Neurology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1130198
American Medical Association (AMA)
Ho, Ying-Jui& Weng, Jun-Cheng& Lin, Chih-Li& Shen, Mei-Shiuan& Li, Hsin-Hua& Liao, Wen-Chieh…[et al.]. Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130198