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18F-FDG-PETCT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging
Joint Authors
Paone, G.
Martucci, F.
Espeli, V.
Treglia, G.
Ruberto, T.
Richetti, A.
Piantanida, R.
Ceriani, Luca
Giovanella, Luca
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study assessed the role of 18F-FDG PET-CT (PET/CT) to detect the cartilage and paraglottic infiltration in advanced glottic cancer comparing the results with those of conventional imaging (CI) (contrast-enhanced computed tomography and/or magnetic resonance).
In addition, we assessed the prognostic value of quantitative parameters, measured on baseline PET/CT, in terms of event-free survival (EFS) and overall survival (OS).
We retrospectively analyzed 27 patients with glottic squamous cell carcinoma stage III and IVA, treated in our institute between 2010 and 2016, comparing PET/CT, performed for staging and radiotherapy planning, and CI findings.
Cohen’s K was used to compare concordance between PET/CT and CI.
Imaging findings were correlated with endoscopic evaluation and histological reports (gold standard (GS)).
All lesions shown by CI were also detected by PET/CT imaging, and in 5 cases, a better definition of local infiltration was achieved with PET/CT than CI (5 CT).
Sensitivity, specificity, and accuracy of PET/CT and CT were 95%, 86%, and 93% and 70%, 86%, and 74% for, respectively.
MRI showed sensitivity and specificity of 100%.
One false-negative (FN) cases and 1 false-positive (FP) case were observed with PET/CT with no difference compared to MRI (10 cases).
Six FN cases and 1 FP case were observed with CT.
Cohen’s K was 0.60 (PET vs.
CI) and 0.80 (PET vs.
GS).
Patients were followed-up for at least 24 months to calculate EFS and OS.
13 local recurrence and 7 deaths were recorded.
Among quantitative PET parameters, baseline MTV was the most powerful predictor of outcome.
Our data suggest a reliable sensitivity and accuracy of PET/CT in the evaluation of local extension, proving a useful method for initial local staging in addition to the well-established role in lymph-node and distant sites assessment.
Furthermore, pretreatment MTV provides better prognostic information than other PET/CT parameters.
American Psychological Association (APA)
Paone, G.& Martucci, F.& Espeli, V.& Ceriani, Luca& Treglia, G.& Ruberto, T.…[et al.]. 2019. 18F-FDG-PETCT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130239
Modern Language Association (MLA)
Paone, G.…[et al.]. 18F-FDG-PETCT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1130239
American Medical Association (AMA)
Paone, G.& Martucci, F.& Espeli, V.& Ceriani, Luca& Treglia, G.& Ruberto, T.…[et al.]. 18F-FDG-PETCT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1130239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130239