Gallium-68-Labelled Indocyanine Green as a Potential Liver Reserve Imaging Agent
Joint Authors
Cai, Liang
Liu, Lin
Chen, Yue
Xia, Yuxiao
Zhang, Li
Zhao, Yanhong
Liu, Xiangdong
Zhang, Wei
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
This work evaluated the potential of 68Ga-labelledNOTA-ICG (1,4,7-triazacyclononane-1,4,7-triacetic acid indocyanine green) for liver reserve imaging.
Methods.
To determine the optimal conditions for generating 68Ga-NOTA-ICG, various reaction parameters were implemented.
Quality control analysis was performed using different chromatography techniques.
The in vitro and in vivo stability was also measured at specific time points.
The radioactivity ratio between n-octanol and water was determined to evaluate the water solubility of 68Ga-NOTA-ICG.
The plasma-protein binding rate of the labelled compound was determined by the methanol method.
The biodistribution and imaging findings were evaluated in normal animals at different time points after injection.
A preliminary imaging evaluation was performed using an animal model of hepatic ischaemia-reperfusion injury, which was confirmed by pathology.
Results.
68Ga-NOTA-ICG was prepared with very high radiochemical purity (>98%) by reacting at 90°C for 10 min at pH = 3.5∼4.0, with excellent stability in vivo and in vitro (>95% 3 h postpreparation).
The in vitro plasma-protein binding rate of 68Ga-NOTA-ICG was 13.01 ± 0.7%, and it showed strong water solubility log P=−2.01±0.04.
We found that in addition to excretion through the biliary tract and intestines, 68Ga-NOTA-ICG can be excreted through the urinary tract.
The image quality of 68Ga-NOTA-ICG was very high; imaging agent retained in the area of liver injury could clearly be observed.
Conclusion.
This is the first report on a 68Ga-labelled NOTA-ICG fragment for liver reserve function studies.
This complex has promise as a candidate agent for liver reserve imaging.
American Psychological Association (APA)
Xia, Yuxiao& Zhang, Li& Zhao, Yanhong& Liu, Xiangdong& Cai, Liang& Liu, Lin…[et al.]. 2019. Gallium-68-Labelled Indocyanine Green as a Potential Liver Reserve Imaging Agent. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1130248
Modern Language Association (MLA)
Xia, Yuxiao…[et al.]. Gallium-68-Labelled Indocyanine Green as a Potential Liver Reserve Imaging Agent. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1130248
American Medical Association (AMA)
Xia, Yuxiao& Zhang, Li& Zhao, Yanhong& Liu, Xiangdong& Cai, Liang& Liu, Lin…[et al.]. Gallium-68-Labelled Indocyanine Green as a Potential Liver Reserve Imaging Agent. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1130248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130248