Gallium-68-Labelled Indocyanine Green as a Potential Liver Reserve Imaging Agent

Joint Authors

Cai, Liang
Liu, Lin
Chen, Yue
Xia, Yuxiao
Zhang, Li
Zhao, Yanhong
Liu, Xiangdong
Zhang, Wei

Source

Contrast Media & Molecular Imaging

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-06-17

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases
Medicine

Abstract EN

Objective.

This work evaluated the potential of 68Ga-labelledNOTA-ICG (1,4,7-triazacyclononane-1,4,7-triacetic acid indocyanine green) for liver reserve imaging.

Methods.

To determine the optimal conditions for generating 68Ga-NOTA-ICG, various reaction parameters were implemented.

Quality control analysis was performed using different chromatography techniques.

The in vitro and in vivo stability was also measured at specific time points.

The radioactivity ratio between n-octanol and water was determined to evaluate the water solubility of 68Ga-NOTA-ICG.

The plasma-protein binding rate of the labelled compound was determined by the methanol method.

The biodistribution and imaging findings were evaluated in normal animals at different time points after injection.

A preliminary imaging evaluation was performed using an animal model of hepatic ischaemia-reperfusion injury, which was confirmed by pathology.

Results.

68Ga-NOTA-ICG was prepared with very high radiochemical purity (>98%) by reacting at 90°C for 10 min at pH = 3.5∼4.0, with excellent stability in vivo and in vitro (>95% 3 h postpreparation).

The in vitro plasma-protein binding rate of 68Ga-NOTA-ICG was 13.01 ± 0.7%, and it showed strong water solubility log P=−2.01±0.04.

We found that in addition to excretion through the biliary tract and intestines, 68Ga-NOTA-ICG can be excreted through the urinary tract.

The image quality of 68Ga-NOTA-ICG was very high; imaging agent retained in the area of liver injury could clearly be observed.

Conclusion.

This is the first report on a 68Ga-labelled NOTA-ICG fragment for liver reserve function studies.

This complex has promise as a candidate agent for liver reserve imaging.

American Psychological Association (APA)

Xia, Yuxiao& Zhang, Li& Zhao, Yanhong& Liu, Xiangdong& Cai, Liang& Liu, Lin…[et al.]. 2019. Gallium-68-Labelled Indocyanine Green as a Potential Liver Reserve Imaging Agent. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1130248

Modern Language Association (MLA)

Xia, Yuxiao…[et al.]. Gallium-68-Labelled Indocyanine Green as a Potential Liver Reserve Imaging Agent. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1130248

American Medical Association (AMA)

Xia, Yuxiao& Zhang, Li& Zhao, Yanhong& Liu, Xiangdong& Cai, Liang& Liu, Lin…[et al.]. Gallium-68-Labelled Indocyanine Green as a Potential Liver Reserve Imaging Agent. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1130248

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1130248