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Effects of Ficus umbellata (Moraceae) Aqueous Extract and 7-Methoxycoumarin on Scopolamine-Induced Spatial Memory Impairment in Ovariectomized Wistar Rats
Joint Authors
Zingue, Stephane
Njamen, Dieudonné
Djiogue, Sefirin
Ezo’o Ezo’o, Yannick
Abaïssou, Hervé Hervé Ngatanko
Fachagbo, Pafroumi
Foyet, Harquin Simplice
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The present work was undertaken to evaluate the ability of F.
umbellata aqueous extract and its major component 7-methoxycoumarin (MC) to improve scopolamine-induced spatial memory impairment in ovariectomized Wistar rats.
For this to be done, 10 sham-operated and 30 postmenopausal-like rats were randomly distributed in eight groups (n=5) and treated with distilled water (2 mL/250 g), estradiol valerate (1 mg/kg BW), piracetam (1.5 mg/kg BW), F.
umbellata aqueous extract (50 and 200 mg/kg BW), or MC (1 mg/kg BW) for 21 consecutive days.
Before and after the memory impairment with scopolamine (2 mg/kg BW), animals underwent behavioral evaluations on Y- and radial mazes.
As results, age and ovariectomy did not induce significant changes in the reference memory errors.
While age decreased working memory errors, ovariectomy increased it.
The MC as well as F.
umbellata extract significantly increased (p<0.01) the percentage of spontaneous alternation and decreased (p<0.001) working and spatial reference memory errors and anxiety parameters (rearing and grooming) in ovariectomized rats.
MC significantly reduced (p<0.05) the MDA level, but resulted in an increase in GSH level in brain homogenates.
These results suggest that MC is endowed with neuroprotective effects and could account for the neuroprotective effects of F.
umbellata in rats.
American Psychological Association (APA)
Zingue, Stephane& Foyet, Harquin Simplice& Djiogue, Sefirin& Ezo’o Ezo’o, Yannick& Abaïssou, Hervé Hervé Ngatanko& Fachagbo, Pafroumi…[et al.]. 2018. Effects of Ficus umbellata (Moraceae) Aqueous Extract and 7-Methoxycoumarin on Scopolamine-Induced Spatial Memory Impairment in Ovariectomized Wistar Rats. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1130262
Modern Language Association (MLA)
Zingue, Stephane…[et al.]. Effects of Ficus umbellata (Moraceae) Aqueous Extract and 7-Methoxycoumarin on Scopolamine-Induced Spatial Memory Impairment in Ovariectomized Wistar Rats. Behavioural Neurology No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1130262
American Medical Association (AMA)
Zingue, Stephane& Foyet, Harquin Simplice& Djiogue, Sefirin& Ezo’o Ezo’o, Yannick& Abaïssou, Hervé Hervé Ngatanko& Fachagbo, Pafroumi…[et al.]. Effects of Ficus umbellata (Moraceae) Aqueous Extract and 7-Methoxycoumarin on Scopolamine-Induced Spatial Memory Impairment in Ovariectomized Wistar Rats. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1130262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130262