Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice
Joint Authors
Zhou, Liang Fu
Yang, Heng
Ni, Wei
Jiang, Hanqiang
Lei, Yu
Su, Jiabin
Gu, Yuxiang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice.
Methods.
An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice.
The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH.
The hematoma volume and hemoglobin level were measured to examine hematoma resolution.
A behavior test and brain edema and white matter injury examinations indicated brain injury after ICH.
Results.
Scriptaid treatment promoted hematoma resolution and reduced the hematoma volume 7 d after ICH compared with the vehicle group (P<0.05).
Scriptaid treatment also alleviated the brain water content in the ipsilateral basal ganglia (P<0.05) and cortex (P<0.01) 3 d after ICH.
In addition, Scriptaid improved neurological function recovery and alleviated white matter injury 35 d after ICH.
Conclusions.
Scriptaid can protect against brain injury after ICH and may be considered a new medical therapy method for ICH.
American Psychological Association (APA)
Yang, Heng& Ni, Wei& Jiang, Hanqiang& Lei, Yu& Su, Jiabin& Gu, Yuxiang…[et al.]. 2018. Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130281
Modern Language Association (MLA)
Yang, Heng…[et al.]. Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice. Behavioural Neurology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1130281
American Medical Association (AMA)
Yang, Heng& Ni, Wei& Jiang, Hanqiang& Lei, Yu& Su, Jiabin& Gu, Yuxiang…[et al.]. Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130281
