MR Angiography of the HeadNeck Vascular System in Mice on a Clinical MRI System
Joint Authors
Thöne-Reineke, Christa
Reimann, Carolin
Brangsch, Julia
Adams, Lisa Christine
Hamm, Bernd
Makowski, Marcus Richard
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Magnetic resonance angiography (MRA) represents a clinical reference standard for the in vivo assessment of the vasculature.
In this study, the potential of non-contrast-enhanced and contrast-enhanced angiography of the head/neck vasculature in mice on a clinical MR imaging system was tested.
Methods.
All in vivo magnetic resonance imaging was performed with a 3T clinical system (Siemens).
Non-contrast-enhanced (time-of-flight, TOF) and contrast-enhanced angiography (gadofosveset-trisodium, GdT) were performed in C57BL/6J mouse strain.
Lumen-to-muscle ratios (LMRs) and area measurements were assessed.
Histology was performed as reference standard of all relevant vascular structures.
Results.
A close correlation between TOF (R2 = 0.79; p<0.05) and contrast-enhanced (GdT) angiography (R2 = 0.92; p<0.05) with histological area measurements was found.
LMRs were comparable between both sequences.
Regarding interobserver reproducibility, contrast-enhanced (GdT) angiography yielded a smaller 95% confidence interval and a closer interreader correlation compared to non-contrast-enhanced (TOF) measurements (−0.73–0.89; R2 = 0.81 vs.
−0.55–0.56; R2 = 0.94).
Conclusion.
This study demonstrates that non-contrast-enhanced and contrast-enhanced angiographies of the head/neck vasculature of small animals can reliably performed on a clinical 3T MR scanner.
Contrast-enhanced angiography enables the visualization of vascular structures with higher intravascular contrast and higher reproducibility.
American Psychological Association (APA)
Reimann, Carolin& Brangsch, Julia& Adams, Lisa Christine& Thöne-Reineke, Christa& Hamm, Bernd& Makowski, Marcus Richard. 2019. MR Angiography of the HeadNeck Vascular System in Mice on a Clinical MRI System. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1130282
Modern Language Association (MLA)
Reimann, Carolin…[et al.]. MR Angiography of the HeadNeck Vascular System in Mice on a Clinical MRI System. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1130282
American Medical Association (AMA)
Reimann, Carolin& Brangsch, Julia& Adams, Lisa Christine& Thöne-Reineke, Christa& Hamm, Bernd& Makowski, Marcus Richard. MR Angiography of the HeadNeck Vascular System in Mice on a Clinical MRI System. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1130282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130282