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Contrast-Enhanced MRI Texture Parameters as Potential Prognostic Factors for Primary Central Nervous System Lymphoma Patients Receiving High-Dose Methotrexate-Based Chemotherapy
Joint Authors
Ma, Xuelei
Chen, Chaoyue
Zhuo, Hongyu
Wei, Xiawei
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
The purpose of this study was to evaluate the prognostic value of texture features on contrast-enhanced magnetic resonance imaging (MRI) for patients with primary central nervous system lymphoma (PCNSL).
Methods.
In this retrospective study, fifty-two patients diagnosed with PCNSL were enrolled from October 2010 to March 2017.
The texture feature of tumor tissue on the histogram-based matrix (histo-) and the grey-level co-occurrence matrix (GLCM) was retrieved by contrast-enhanced T1-weighted imaging before any antitumor treatment.
Receiver operating characteristic curve analyses were performed to obtain their optimal cutoff values, based on which we dichotomized patients into subgroups.
The Kaplan–Meier analyses were conducted to compare overall survival (OS) of subgroups, and multivariate Cox regression analyses were used to determine if they could be taken as independent prognostic factors.
Results.
Ten texture features were extracted from the MR image, including Energy, Entropy, Kurtosis, Skewness on the histogram-based matrix, and Correlation, Contrast, Dissimilarity, Energy, Entropy, and Homogeneity on the grey-level co-occurrence matrix.
Three of them (GLCM-Contrast, GLCM-Dissimilarity, and GLCM-Homogeneity) are shown to be significant in relation to overall survival (OS).
The multivariate Cox regression analyses suggest that GLCM-Homogeneity could be taken as independent predictors.
Conclusions.
The texture features of contrast-enhanced magnetic resonance imaging (MRI) could potentially serve as prognostic biomarkers for PCNSL patients.
American Psychological Association (APA)
Chen, Chaoyue& Zhuo, Hongyu& Wei, Xiawei& Ma, Xuelei. 2019. Contrast-Enhanced MRI Texture Parameters as Potential Prognostic Factors for Primary Central Nervous System Lymphoma Patients Receiving High-Dose Methotrexate-Based Chemotherapy. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1130284
Modern Language Association (MLA)
Chen, Chaoyue…[et al.]. Contrast-Enhanced MRI Texture Parameters as Potential Prognostic Factors for Primary Central Nervous System Lymphoma Patients Receiving High-Dose Methotrexate-Based Chemotherapy. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1130284
American Medical Association (AMA)
Chen, Chaoyue& Zhuo, Hongyu& Wei, Xiawei& Ma, Xuelei. Contrast-Enhanced MRI Texture Parameters as Potential Prognostic Factors for Primary Central Nervous System Lymphoma Patients Receiving High-Dose Methotrexate-Based Chemotherapy. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1130284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130284