Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging
Joint Authors
Lehto, Vesa-Pekka
Soikkeli, Maiju
Kettunen, Mikko I.
Nivajärvi, Riikka
Olsson, Venla
Rönkkö, Seppo
Laakkonen, Johanna P.
Kavakka, Jari
Heikkinen, Sami
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Magnetic resonance imaging examinations are frequently carried out using contrast agents to improve the image quality.
Practically all clinically used contrast agents are based on paramagnetic metals and lack in selectivity and specificity.
A group of stable organic radicals, nitroxides, has raised interest as new metal-free contrast agents for MRI.
Their structures can easily be modified to incorporate different functionalities.
In the present study, a stable nitroxide TEEPO (2,2,6,6-tetraethylpiperidin-1-oxyl) was linked to a glucose moiety (Glc) to construct a water-soluble, potentially tumor-targeting compound with contrast-enhancing ability.
The ability was assessed with in vivo MRI experiments.
The constructed TEEPO-Glc agent proved to shorten the T1 relaxation time in tumor, while the T1 time in healthy brain tissue remained the same.
The results indicate the potential of TEEPO-Glc as a valuable addition to the growing field of metal-free contrast enhancement in MRI-based diagnostics.
American Psychological Association (APA)
Soikkeli, Maiju& Kettunen, Mikko I.& Nivajärvi, Riikka& Olsson, Venla& Rönkkö, Seppo& Laakkonen, Johanna P.…[et al.]. 2019. Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1130286
Modern Language Association (MLA)
Soikkeli, Maiju…[et al.]. Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1130286
American Medical Association (AMA)
Soikkeli, Maiju& Kettunen, Mikko I.& Nivajärvi, Riikka& Olsson, Venla& Rönkkö, Seppo& Laakkonen, Johanna P.…[et al.]. Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1130286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130286