3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment
Joint Authors
Rodriguez-Garcia, Aida
Oliva-Ramirez, Jacqueline
Bautista-Flores, Claudia
Hosseini, Samira
Source
Advances in Polymer Technology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-41, 41 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-10
Country of Publication
Egypt
No. of Pages
41
Main Subjects
Abstract EN
The past few decades have shown significant advancement as complex in vitro humanized systems have substituted animal trials and 2D in vitro studies.
3D humanized platforms mimic the organs of interest with their stimulations (physical, electrical, chemical, and mechanical).
Organ-on-chip devices, including in vitro modelling of 3D organoids, 3D microfabrication, and 3D bioprinted platforms, play an essential role in drug discovery, testing, and assessment.
In this article, a thorough review is provided of the latest advancements in the area of organ-on-chip devices targeting liver, kidney, lung, gut, heart, skin, and brain mimicry devices for drug discovery, development, and/or assessment.
The current strategies, fabrication methods, and the specific application of each device, as well as the advantages and disadvantages, are presented for each reported platform.
This comprehensive review also provides some insights on the challenges and future perspectives for the further advancement of each organ-on-chip device.
American Psychological Association (APA)
Rodriguez-Garcia, Aida& Oliva-Ramirez, Jacqueline& Bautista-Flores, Claudia& Hosseini, Samira. 2020. 3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment. Advances in Polymer Technology،Vol. 2020, no. 2020, pp.1-41.
https://search.emarefa.net/detail/BIM-1130293
Modern Language Association (MLA)
Rodriguez-Garcia, Aida…[et al.]. 3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment. Advances in Polymer Technology No. 2020 (2020), pp.1-41.
https://search.emarefa.net/detail/BIM-1130293
American Medical Association (AMA)
Rodriguez-Garcia, Aida& Oliva-Ramirez, Jacqueline& Bautista-Flores, Claudia& Hosseini, Samira. 3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment. Advances in Polymer Technology. 2020. Vol. 2020, no. 2020, pp.1-41.
https://search.emarefa.net/detail/BIM-1130293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130293