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The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease
Joint Authors
Zhao, Shoucai
Zhang, Ji
Ma, Lingsong
Li, Shizun
Huang, Tingting
Chu, Zhaohu
Xu, Yang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Necroptosis is the best-described form of regulated necrosis at present, which is widely recognized as a component of caspase-independent cell death mediated by the concerted action of receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3).
Mixed-lineage kinase domain-like (MLKL) was phosphorylated by RIPK3 at the threonine 357 and serine 358 residues and then formed tetramers and translocated onto the plasma membrane, which destabilizes plasma membrane integrity leading to cell swelling and membrane rupture.
Necroptosis is downstream of the tumor necrosis factor (TNF) receptor family, and also interaction with NOD-like receptor pyrin 3 (NLRP3) induced inflammasome activation.
Multiple inhibitors of RIPK1 and MLKL have been developed to block the cascade of signal pathways for procedural necrosis and represent potential leads for drug development.
In this review, we highlight recent progress in the study of roles for necroptosis in cerebral ischemic disease and discuss how these modifications delicately control necroptosis.
American Psychological Association (APA)
Xu, Yang& Zhang, Ji& Ma, Lingsong& Zhao, Shoucai& Li, Shizun& Huang, Tingting…[et al.]. 2018. The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130302
Modern Language Association (MLA)
Xu, Yang…[et al.]. The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease. Behavioural Neurology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1130302
American Medical Association (AMA)
Xu, Yang& Zhang, Ji& Ma, Lingsong& Zhao, Shoucai& Li, Shizun& Huang, Tingting…[et al.]. The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130302