Metabolic Risk Factors of Alzheimer’s Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study
Joint Authors
Tai, Hsu-Chih
Kung, Woon-Man
Cheng, Chih-Kuang
Tsao, Yu-Chien
Su, Yuan-Chih
Sung, Fung-Chang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) share many risk factors.
Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear.
The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain.
Thus, this nationwide, population-based study was designed to evaluate the metabolic and CVD risks in AD and DLB.
Materials and Methods.
Data were obtained from the Taiwan National Health Insurance Research Database.
AD patients, DLB patients, and normal control (NC) individuals from 1996 to 2013 were enrolled for risk assessment.
Results.
In total, 7544 NC individuals, 1324 AD patients, and 562 DLB patients were enrolled.
Participants with one or more metabolic risk factors had significantly higher odds of AD or DLB.
No significant differences in metabolic risk factors were observed between DLB and AD patients.
AD patients had a lower risk of CVD (aHR = 0.67, 95% CI = 0.59–0.76, p value < 0.001) and coronary artery disease (CAD) (aHR = 0.59, 95% CI = 0.51–0.69, p value < 0.001) than NC.
DLB patients had a higher risk of ischemic stroke (aHR = 2.27, 95% CI = 1.68–3.06, p value < 0.001) than NC.
Conclusion.
Metabolic risk factors are important in AD and DLB.
Patients with AD might have a lower risk of CAD and ischemic strokes.
Patients with DLB might have a higher risk of ischemic stroke.
American Psychological Association (APA)
Cheng, Chih-Kuang& Tsao, Yu-Chien& Su, Yuan-Chih& Sung, Fung-Chang& Tai, Hsu-Chih& Kung, Woon-Man. 2018. Metabolic Risk Factors of Alzheimer’s Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130330
Modern Language Association (MLA)
Cheng, Chih-Kuang…[et al.]. Metabolic Risk Factors of Alzheimer’s Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study. Behavioural Neurology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1130330
American Medical Association (AMA)
Cheng, Chih-Kuang& Tsao, Yu-Chien& Su, Yuan-Chih& Sung, Fung-Chang& Tai, Hsu-Chih& Kung, Woon-Man. Metabolic Risk Factors of Alzheimer’s Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130330