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Ganoderma lucidum Polysaccharide (GLP) Inhibited the Progression of Oral Squamous Cell Carcinoma via the miR-188BCL9β-Catenin Pathway
Joint Authors
Source
Advances in Polymer Technology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
The effects of Ganoderma lucidum polysaccharide (GLP) on the proliferation and migration of oral squamous cell carcinoma (OSCC) cells (HSC-3) were investigated in this study.
Methods.
Oral squamous cell carcinoma (OSCC) cells (HSC-3) were cultured in vitro and were treated with different concentrations of GLP.
CCK-8 assay and scratch assay were then used to detect the inhibitory effect of GLP on these cells.
qRT-PCR and western blot were used to measure the expression changes of the genes involved in the miR-188 and β-catenin signaling pathways.
Results.
GLP had significant cytotoxicity to HSC-3 cells and was capable of inhibiting the proliferation and migration of HSC-3 cells.
GLP upregulated the expression of miR-188 in HSC-3 cells and via which inhibited the proliferation and migration of HSC-3 cells.
In addition, miR-188 inhibited the activation of the β-catenin signaling pathway through its target BCL9.
Conclusions.
GLP inhibited the proliferation and migration of OSCC cells (HSC-3) by regulating the miR-188/BCL9/β-catenin signaling pathway.
The results in this study provided a theoretical basis for the treatment of OSCC with GLP.
American Psychological Association (APA)
Zeng, Zhigang& Xiao, Kaiyan. 2020. Ganoderma lucidum Polysaccharide (GLP) Inhibited the Progression of Oral Squamous Cell Carcinoma via the miR-188BCL9β-Catenin Pathway. Advances in Polymer Technology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1130361
Modern Language Association (MLA)
Zeng, Zhigang& Xiao, Kaiyan. Ganoderma lucidum Polysaccharide (GLP) Inhibited the Progression of Oral Squamous Cell Carcinoma via the miR-188BCL9β-Catenin Pathway. Advances in Polymer Technology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1130361
American Medical Association (AMA)
Zeng, Zhigang& Xiao, Kaiyan. Ganoderma lucidum Polysaccharide (GLP) Inhibited the Progression of Oral Squamous Cell Carcinoma via the miR-188BCL9β-Catenin Pathway. Advances in Polymer Technology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1130361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130361