Fe-HBED Analogs: A Promising Class of Iron-Chelate Contrast Agents for Magnetic Resonance Imaging
Joint Authors
Bales, Brian C.
Grimmond, Brian
Johnson, Bruce F.
Luttrell, M. Todd
Meyer, Dan E.
Polyanskaya, Tatyana
Rishel, Michael J.
Roberts, Jeannette
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Contrast-enhanced magnetic resonance imaging is an essential tool for disease diagnosis and management; all marketed clinical magnetic resonance imaging (MRI) contrast agents (CAs) are gadolinium (Gd) chelates and most are extracellular fluid (ECF) agents.
After intravenous injection, these agents rapidly distribute to the extracellular space and are also characterized by low serum protein binding and predominant renal clearance.
Gd is an abiotic element with no biological recycling processes; low levels of Gd have been detected in the central nervous system and bone long after administration.
These observations have prompted interest in the development of new MRI contrast agents based on biotic elements such as iron (Fe); Fe-HBED (HBED = N,N′-bis(2-hydroxyphenyl)ethylenediamine-N,N′-diacetic acid), a coordinatively saturated iron chelate, is an attractive MRI CA platform suitable for modification to adjust relaxivity and biodistribution.
Compared to the parent Fe-HBED, the Fe-HBED analogs reported here have lower serum protein binding and higher relaxivity as well as lower relative liver enhancement in mice, comparable to that of a representative gadolinium-based contrast agent (GBCA).
Fe-HBED analogs are therefore a promising class of non-Gd ECF MRI CA.
American Psychological Association (APA)
Bales, Brian C.& Grimmond, Brian& Johnson, Bruce F.& Luttrell, M. Todd& Meyer, Dan E.& Polyanskaya, Tatyana…[et al.]. 2019. Fe-HBED Analogs: A Promising Class of Iron-Chelate Contrast Agents for Magnetic Resonance Imaging. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130364
Modern Language Association (MLA)
Bales, Brian C.…[et al.]. Fe-HBED Analogs: A Promising Class of Iron-Chelate Contrast Agents for Magnetic Resonance Imaging. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1130364
American Medical Association (AMA)
Bales, Brian C.& Grimmond, Brian& Johnson, Bruce F.& Luttrell, M. Todd& Meyer, Dan E.& Polyanskaya, Tatyana…[et al.]. Fe-HBED Analogs: A Promising Class of Iron-Chelate Contrast Agents for Magnetic Resonance Imaging. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130364