Functional Connectivity Changes in Behavioral, Semantic, and Nonfluent Variants of Frontotemporal Dementia
Joint Authors
Santamaría-García, Hernando
Reyes, P.
Ortega-Merchan, M. P.
Rueda, A.
Uriza, F.
Rojas-Serrano, N.
Rodriguez-Santos, J.
Velasco-Leon, M. C.
Rodriguez-Parra, J. D.
Mora-Diaz, D. E.
Matallana, D.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Frontotemporal dementia (FTD) affects behavior, language, and personality.
This study aims to explore functional connectivity changes in three FTD variants: behavioral (bvFTD), semantic (svPPA), and nonfluent variant (nfvPPA).
Seventy-six patients diagnosed with FTD by international criteria and thirty-two controls were investigated.
Functional connectivity from resting functional magnetic resonance imaging (fMRI) was estimated for the whole brain.
Two types of analysis were done: network basic statistic and topological measures by graph theory.
Several hubs in the limbic system and basal ganglia were compromised in the behavioral variant apart from frontal networks.
Nonfluent variants showed a major disconnection with respect to the behavioral variant in operculum and parietal inferior.
The global efficiency had lower coefficients in nonfluent variants than behavioral variants and controls.
Our results support an extensive disconnection among frontal, limbic, basal ganglia, and parietal hubs.
American Psychological Association (APA)
Reyes, P.& Ortega-Merchan, M. P.& Rueda, A.& Uriza, F.& Santamaría-García, Hernando& Rojas-Serrano, N.…[et al.]. 2018. Functional Connectivity Changes in Behavioral, Semantic, and Nonfluent Variants of Frontotemporal Dementia. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130381
Modern Language Association (MLA)
Reyes, P.…[et al.]. Functional Connectivity Changes in Behavioral, Semantic, and Nonfluent Variants of Frontotemporal Dementia. Behavioural Neurology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1130381
American Medical Association (AMA)
Reyes, P.& Ortega-Merchan, M. P.& Rueda, A.& Uriza, F.& Santamaría-García, Hernando& Rojas-Serrano, N.…[et al.]. Functional Connectivity Changes in Behavioral, Semantic, and Nonfluent Variants of Frontotemporal Dementia. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1130381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130381