Influence of the Preparation Method on Some Characteristics of AlginateChitosanLovastatin Composites
Joint Authors
Thai, Hoang
Tran, Lam D.
Nghiem, Duc-Thuan
Nguyen, Thuy-Chinh
Do, Minh-Thanh
Nguyen, Thi-Huyen
Hoang, Tran-Dung
Le, Van-Quan
Vu, Quoc-Trung
Nguyen, Duy-Trinh
Source
Advances in Polymer Technology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study investigates the effects of direct and indirect dispersion methods for lovastatin solid dispersion (LSD) in alginate (AG)/chitosan (CS) composites on the characteristics and properties of the AG/CS/LSD composites.
The preparation method significantly influences the structure, morphology, and LSD size distribution of the composites as well as the drug release of LSD from the samples.
The differences in dispersion methods for LSD lead to differences in the interaction between the components, the structure, and the control drug release of LSD.
Lovastatin was released from the samples containing LSD in two stages (a fast release stage and a slow release stage), and the drug release content prepared using the indirect method is lower than that prepared using the direct method in the same buffer solution.
After 32 h of testing, the released LSD content from the indirect and direct LSD dispersion methods in pH 2 and pH 7.4 buffer solutions was 87–94% and 41–61%, respectively.
Drug release kinetics from the above samples in solutions with different pH values was also set up.
American Psychological Association (APA)
Nghiem, Duc-Thuan& Nguyen, Thuy-Chinh& Do, Minh-Thanh& Nguyen, Thi-Huyen& Tran, Lam D.& Hoang, Tran-Dung…[et al.]. 2020. Influence of the Preparation Method on Some Characteristics of AlginateChitosanLovastatin Composites. Advances in Polymer Technology،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1130384
Modern Language Association (MLA)
Nghiem, Duc-Thuan…[et al.]. Influence of the Preparation Method on Some Characteristics of AlginateChitosanLovastatin Composites. Advances in Polymer Technology No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1130384
American Medical Association (AMA)
Nghiem, Duc-Thuan& Nguyen, Thuy-Chinh& Do, Minh-Thanh& Nguyen, Thi-Huyen& Tran, Lam D.& Hoang, Tran-Dung…[et al.]. Influence of the Preparation Method on Some Characteristics of AlginateChitosanLovastatin Composites. Advances in Polymer Technology. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1130384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130384