Influences of Oldenlandia diffusa on the CYP450 Activities in Rats Using a Cocktail Method by UHPLC-MSMS
Joint Authors
Lin, Yiping
Wei, Yanli
Hu, Xiaoxia
Wu, Meilling
Ying, Xiaoqian
Ding, Mingxing
Source
Biochemistry Research International
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Oldenlandia diffusa has been used to treat various cancers.
Cytochrome P450, a drug metabolic enzyme, might be influenced by herbal medicine.
Currently, the problem that remains is the effective treatment in drug-drug interaction situation.
Potential influences of Oldenlandia diffusa were elucidated on the CYP450 activities in rats using a cocktail method.
Blood samples were precipitated by acetonitrile.
Quantitative determination of target test object was done by ultra-performance liquid chromatography tandem mass spectrometry detection.
Influences of oldenlandia diffusa on the activities of five CYP450 subtypes in rats were evaluated by five specific probe drugs (phenacetin for CYP1A2, omeprazole for CYP2C19, tolbutamide for CYP2C9, metoprolol for CYP2D6, and midazolam for CYP3A4) according to the pharmacokinetic parameters changes.
No statistically significant difference (P>0.05) in pharmacokinetic behaviors can be observed in the five probe drugs.
There is a potential guidance on clinical drug combination with Oldenlandia diffusa.
Oldenlandia diffusa in compound preparation showed well security.
American Psychological Association (APA)
Lin, Yiping& Wei, Yanli& Hu, Xiaoxia& Wu, Meilling& Ying, Xiaoqian& Ding, Mingxing. 2018. Influences of Oldenlandia diffusa on the CYP450 Activities in Rats Using a Cocktail Method by UHPLC-MSMS. Biochemistry Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1130386
Modern Language Association (MLA)
Lin, Yiping…[et al.]. Influences of Oldenlandia diffusa on the CYP450 Activities in Rats Using a Cocktail Method by UHPLC-MSMS. Biochemistry Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1130386
American Medical Association (AMA)
Lin, Yiping& Wei, Yanli& Hu, Xiaoxia& Wu, Meilling& Ying, Xiaoqian& Ding, Mingxing. Influences of Oldenlandia diffusa on the CYP450 Activities in Rats Using a Cocktail Method by UHPLC-MSMS. Biochemistry Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1130386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130386