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Streptozotocin-Induced Adaptive Modification of Mitochondrial Supercomplexes in Liver of Wistar Rats and the Protective Effect of Moringa oleifera Lam
Joint Authors
Flores-Herrera, Oscar
Téllez-Valencia, Alfredo
Sierra-Campos, Erick
Valdez-Solana, Mónica A.
García-Arenas, Guadalupe
Alejandra Sánchez-Muñoz, María
Campos-Almazán, Mara Ibeth
Esparza-Perusquía, Mercedes
Olvera-Sánchez, Sofia
Avitia-Domínguez, Claudia
Source
Biochemistry Research International
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-01
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The increasing prevalence of diabetes continues to be a major health issue worldwide.
Alteration of mitochondrial electron transport chain is a recognized hallmark of the diabetic-associated decline in liver bioenergetics; however, the molecular events involved are only poorly understood.
Moringa oleifera is used for the treatment of diabetes.
However, its role on mitochondrial functionality is not yet established.
This study was aimed to evaluate the effect of M.
oleifera extract on supercomplex formation, ATPase activity, ROS production, GSH levels, lipid peroxidation, and protein carbonylation.
The levels of lipid peroxidation and protein carbonylation were increased in diabetic group.
However, the levels were decreased in Moringa-treated diabetic rats.
Analysis of in-gel activity showed an increase in all complex activities in the diabetic group, but spectrophotometric determinations of complex II and IV activities were unaffected in this treatment.
However, we found an oxygen consumption abolition through complex I-III-IV pathway in the diabetic group treated with Moringa.
While respiration with succinate feeding into complex II-III-IV was increased in the diabetic group.
These findings suggest that hyperglycemia modifies oxygen consumption, supercomplexes formation, and increases ROS levels in mitochondria from the liver of STZ-diabetic rats, whereas M.
oleifera may have a protective role against some alterations.
American Psychological Association (APA)
Alejandra Sánchez-Muñoz, María& Valdez-Solana, Mónica A.& Campos-Almazán, Mara Ibeth& Flores-Herrera, Oscar& Esparza-Perusquía, Mercedes& Olvera-Sánchez, Sofia…[et al.]. 2018. Streptozotocin-Induced Adaptive Modification of Mitochondrial Supercomplexes in Liver of Wistar Rats and the Protective Effect of Moringa oleifera Lam. Biochemistry Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1130389
Modern Language Association (MLA)
Alejandra Sánchez-Muñoz, María…[et al.]. Streptozotocin-Induced Adaptive Modification of Mitochondrial Supercomplexes in Liver of Wistar Rats and the Protective Effect of Moringa oleifera Lam. Biochemistry Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1130389
American Medical Association (AMA)
Alejandra Sánchez-Muñoz, María& Valdez-Solana, Mónica A.& Campos-Almazán, Mara Ibeth& Flores-Herrera, Oscar& Esparza-Perusquía, Mercedes& Olvera-Sánchez, Sofia…[et al.]. Streptozotocin-Induced Adaptive Modification of Mitochondrial Supercomplexes in Liver of Wistar Rats and the Protective Effect of Moringa oleifera Lam. Biochemistry Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1130389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130389