Nanoparticle-Based Contrast Agents for 129Xe HyperCEST NMR and MRI Applications
Joint Authors
Jayapaul, Jabadurai
Schröder, Leif
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-22
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
Spin hyperpolarization techniques have enabled important advancements in preclinical and clinical MRI applications to overcome the intrinsic low sensitivity of nuclear magnetic resonance.
Functionalized xenon biosensors represent one of these approaches.
They combine two amplification strategies, namely, spin exchange optical pumping (SEOP) and chemical exchange saturation transfer (CEST).
The latter one requires host structures that reversibly bind the hyperpolarized noble gas.
Different nanoparticle approaches have been implemented and have enabled molecular MRI with 129Xe at unprecedented sensitivity.
This review gives an overview of the Xe biosensor concept, particularly how different nanoparticles address various critical aspects of gas binding and exchange, spectral dispersion for multiplexing, and targeted reporter delivery.
As this concept is emerging into preclinical applications, comprehensive sensor design will be indispensable in translating the outstanding sensitivity potential into biomedical molecular imaging applications.
American Psychological Association (APA)
Jayapaul, Jabadurai& Schröder, Leif. 2019. Nanoparticle-Based Contrast Agents for 129Xe HyperCEST NMR and MRI Applications. Contrast Media & Molecular Imaging،Vol. 2019, no. 2019, pp.1-25.
https://search.emarefa.net/detail/BIM-1130393
Modern Language Association (MLA)
Jayapaul, Jabadurai& Schröder, Leif. Nanoparticle-Based Contrast Agents for 129Xe HyperCEST NMR and MRI Applications. Contrast Media & Molecular Imaging No. 2019 (2019), pp.1-25.
https://search.emarefa.net/detail/BIM-1130393
American Medical Association (AMA)
Jayapaul, Jabadurai& Schröder, Leif. Nanoparticle-Based Contrast Agents for 129Xe HyperCEST NMR and MRI Applications. Contrast Media & Molecular Imaging. 2019. Vol. 2019, no. 2019, pp.1-25.
https://search.emarefa.net/detail/BIM-1130393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130393