Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers
Joint Authors
Srinivasan, Mythily
Meadows, Melinda L.
Maxwell, Lisa
Source
Biochemistry Research International
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2DM) is emerging as a metabolic epidemic worldwide.
Pathologically, dysregulation of many biological pathways precedes hyperglycemia and the clinical diagnosis of T2DM.
Changing trajectories along the process of T2DM development necessitates frequent measurement of biomarkers for early identification of at-risk individuals and successful prevention.
Increase in circulating inflammatory adipokines has been suggested as predictive of T2DM.
Human saliva is an easily accessible biospecimen amenable for painless frequent collection and possesses nearly 50% of serum proteome.
In this study, we measured the adipokines resistin, visfatin, TNF-α, and ghrelin as markers for T2DM in unstimulated whole saliva (UWS) using specific assay kits.
Resistin and visfatin concentrations were significantly higher in T2DM saliva.
Although the concentration of acylated or unacylated ghrelin was lower in diabetic saliva, the decrease was not significant.
Since resistin and visfatin are biomarkers integral to T2DM pathology, their salivary assessments may receive clinical acceptance.
American Psychological Association (APA)
Srinivasan, Mythily& Meadows, Melinda L.& Maxwell, Lisa. 2018. Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers. Biochemistry Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1130395
Modern Language Association (MLA)
Srinivasan, Mythily…[et al.]. Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers. Biochemistry Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1130395
American Medical Association (AMA)
Srinivasan, Mythily& Meadows, Melinda L.& Maxwell, Lisa. Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers. Biochemistry Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1130395
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130395