Efficacy of Dexmedetomidine versus Ketofol for Sedation of Postoperative Mechanically Ventilated Patients with Obstructive Sleep Apnea
Joint Authors
Elmoutaz Mahmoud, Hatem
Rashwan, Doaa Abou Elkassim
Source
Critical Care Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Patients with sleep apnea are prone to postoperative respiratory complications, requiring restriction of sedatives during perioperative care.
We performed a prospective randomized study on 24 patients with obstructive sleep apnea (OSA) who underwent elective surgery under general anesthesia.
The patients were equally divided into two groups: Group Dex: received dexmedetomidine loading dose 1 mcg/kg IV over 10 min followed by infusion of 0.2–0.7 mcg/kg/hr; Group KFL: received ketofol as an initial bolus dose 500 mcg/kg IV (ketamine/propofol 1 : 1) and maintenance dose of 5–10 mcg/kg/min.
Sedation level (Ramsay sedation score), bispectral index (BIS), duration of mechanical ventilation, surgical intensive care unit (SICU) stay, and mean time to extubation were evaluated.
Complications (hypotension, hypertension, bradycardia, postextubation apnea, respiratory depression, and desaturation) and number of patients requiring reintubation were recorded.
There was a statistically significant difference between the two groups in BIS at the third hour only (Group DEX 63.00 ± 3.542 and Group KFL 66.42 ± 4.010, p value = 0.036).
Duration of mechanical ventilation, SICU stay, and extubation time showed no statistically significant differences.
No complications were recorded in both groups.
Thus, dexmedetomidine was associated with lesser duration of mechanical ventilation and time to extubation than ketofol, but these differences were not statistically significant.
American Psychological Association (APA)
Elmoutaz Mahmoud, Hatem& Rashwan, Doaa Abou Elkassim. 2018. Efficacy of Dexmedetomidine versus Ketofol for Sedation of Postoperative Mechanically Ventilated Patients with Obstructive Sleep Apnea. Critical Care Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130409
Modern Language Association (MLA)
Elmoutaz Mahmoud, Hatem& Rashwan, Doaa Abou Elkassim. Efficacy of Dexmedetomidine versus Ketofol for Sedation of Postoperative Mechanically Ventilated Patients with Obstructive Sleep Apnea. Critical Care Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1130409
American Medical Association (AMA)
Elmoutaz Mahmoud, Hatem& Rashwan, Doaa Abou Elkassim. Efficacy of Dexmedetomidine versus Ketofol for Sedation of Postoperative Mechanically Ventilated Patients with Obstructive Sleep Apnea. Critical Care Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130409