Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release
Joint Authors
Xing, Jinjing
Cai, Yeqiang
Wang, Yikun
Zheng, Haifu
Liu, Yujia
Source
Advances in Polymer Technology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
CaCO3 nanoparticles are very suitable as intelligent carriers because of their ideal biocompatibility and biodegradability, especially their sensitivity to pH.
In this paper, we use mesoporous CaCO3 nanoparticles as intelligent carrier, sodium alginate, and chitosan as alternating assembly materials, folic acid as target molecules, and exploit layer-by-layer assembly technology to achieve sensitive molecular targeting and pH response drug release.
Mesoporous CaCO3 hybrid nanoparticles have high drug loading on doxorubicin.
The effects of different pH values on drug release in vitro were studied by regulating simulated body fluids with different pH values.
The cytotoxicity, targeting effect, and drug release of human cervical cancer cell line (HeLa) were studied by cell vitality and imaging experiments.
All the evidence suggests that the smart mesoporous CaCO3 nanoparticles may be a potential clinical application platform for cancer therapy.
American Psychological Association (APA)
Xing, Jinjing& Cai, Yeqiang& Wang, Yikun& Zheng, Haifu& Liu, Yujia. 2020. Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release. Advances in Polymer Technology،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1130412
Modern Language Association (MLA)
Xing, Jinjing…[et al.]. Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release. Advances in Polymer Technology No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1130412
American Medical Association (AMA)
Xing, Jinjing& Cai, Yeqiang& Wang, Yikun& Zheng, Haifu& Liu, Yujia. Synthesis of Polymer Assembled Mesoporous CaCO3 Nanoparticles for Molecular Targeting and pH-Responsive Controlled Drug Release. Advances in Polymer Technology. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1130412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130412