Emerging Evidence concerning the Role of Sirtuins in Sepsis
Joint Authors
Zeng, Zhenhua
Chen, Zhongqing
Li, Lulan
Fu, Weijun
Cai, Shumin
Source
Critical Care Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sepsis, a dysregulated host response to infection, is a major public health concern.
Though experimental and clinical studies relating to sepsis are increasing, the mechanism of sepsis is not completely understood.
To date, numerous studies have shown that sirtuins (silent mating type information regulation 2 homolog), which belong to the class III histone deacetylases, may have a varied, or even opposite, effect in the pathogenesis of sepsis.
Notably, downstream mechanisms of sirtuins are not fully understood.
The sirtuin family consists of sirtuins 1–7; among them, sirtuin 1 (SIRT1) is the most studied one, during the development of sepsis.
Furthermore, other sirtuin members are also confirmed to be involved in the regulation of inflammatory or metabolic signaling following sepsis.
In addition, sirtuins may interact with each other to form a precise regulatory mechanism in different phases of sepsis.
Therefore, in this review, by accumulating data from PubMed, we intend to explain the role of sirtuin in sepsis, which we hope will pave the way for further experimental study and the potential future clinical applications of sirtuins.
American Psychological Association (APA)
Li, Lulan& Chen, Zhongqing& Fu, Weijun& Cai, Shumin& Zeng, Zhenhua. 2018. Emerging Evidence concerning the Role of Sirtuins in Sepsis. Critical Care Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130441
Modern Language Association (MLA)
Li, Lulan…[et al.]. Emerging Evidence concerning the Role of Sirtuins in Sepsis. Critical Care Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1130441
American Medical Association (AMA)
Li, Lulan& Chen, Zhongqing& Fu, Weijun& Cai, Shumin& Zeng, Zhenhua. Emerging Evidence concerning the Role of Sirtuins in Sepsis. Critical Care Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130441