Creatinine- and Cystatin C-Based Incidence of Chronic Kidney Disease and Acute Kidney Disease in AKI Survivors
Joint Authors
Bottai, Matteo
Rimes-Stigare, Claire
Ravn, Bo
Awad, Akil
Torlén, Klara
Martling, Claes-Roland
Mårtensson, Johan
Bell, Max
Source
Critical Care Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Renal dysfunction after acute kidney injury (AKI) is common, potentially modifiable, but poorly understood.
Acute kidney disease (AKD) describes renal dysfunction 7 to 90 days after AKI and is determined by percentage change in creatinine from baseline.
Chronic kidney disease (CKD) is defined as the estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73 m2 persisting for more than 90 days.
We compared CKD incidence using both creatinine- and cystatin C-based GFR with AKD incidence at 90 days in AKI survivors.
Methods.
A prospective cohort study was conducted in a Swedish intensive care unit (ICU) between 2008 and 2010.
We included AKI patients alive at 90 days.
We excluded patients <18 and >100 years, death before follow-up, CKD prior to admission, and follow-up before 60 days or beyond 270 days.
Creatinine and cystatin C were measured at 90 days and converted to eGFR (mL/min/1.73 m2).
Results.
We included 274 patients.
At 90-day follow-up, the median creatinine eGFR (MDRD) was 81.6 (IQR 58.6–106.8) and median cystatin C eGFR was 51.5 (IQR 35.8–70.7).
The incidence of CKD (eGFR < 60) was 25.8% based on creatinine but 63.7% using cystatin C estimates.
AKD was present in 47 patients (18.9%).
Age, discharge cystatin C, creatinine at discharge, and female gender predicted creatinine-defined CKD at follow-up.
Age, discharge cystatin C, CRRT on ICU, and diabetes were associated with cystatin C-based CKD.
Conclusions.
In AKI survivors followed up at 3 months, CKD criteria were met in a quarter of patients using creatinine and in two-thirds using cystatin C eGFR.
Less than one-fifth of patients fulfilled AKD criteria.
The application of AKD criteria may underestimate renal dysfunction in AKI survivors.
American Psychological Association (APA)
Rimes-Stigare, Claire& Ravn, Bo& Awad, Akil& Torlén, Klara& Martling, Claes-Roland& Bottai, Matteo…[et al.]. 2018. Creatinine- and Cystatin C-Based Incidence of Chronic Kidney Disease and Acute Kidney Disease in AKI Survivors. Critical Care Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130450
Modern Language Association (MLA)
Rimes-Stigare, Claire…[et al.]. Creatinine- and Cystatin C-Based Incidence of Chronic Kidney Disease and Acute Kidney Disease in AKI Survivors. Critical Care Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1130450
American Medical Association (AMA)
Rimes-Stigare, Claire& Ravn, Bo& Awad, Akil& Torlén, Klara& Martling, Claes-Roland& Bottai, Matteo…[et al.]. Creatinine- and Cystatin C-Based Incidence of Chronic Kidney Disease and Acute Kidney Disease in AKI Survivors. Critical Care Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1130450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130450