The Effect of Intraoperative Methadone Compared to Morphine on Postsurgical Pain: A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Alves, Lucas J.
Pence, Kristi
Mukhdomi, Taif
Croxford, Daniel
De Oliveira, Gildasio S.
Kendall, Mark C.
Source
Anesthesiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background and Objectives.
Methadone is commonly used in chronic pain, but it is not frequently used as an intraoperative analgesic.
Several randomized studies have compared intraoperative methadone to morphine regarding postsurgical analgesia, but they have generated conflicting results.
The aim of this investigation was to compare the analgesic efficacy of intraoperative methadone to morphine in patients undergoing surgical procedures.
Methods.
We performed a quantitative systematic review of randomized controlled trials in PubMed, Embase, Cochrane Library, and Google Scholar electronic databases.
Meta-analysis was performed using the random effects model, weighted mean differences (WMD), standard deviation, 95% confidence intervals, and sample size.
Methodological quality was evaluated using Cochrane Collaboration’s tool.
Results.
Seven randomized controlled trials evaluating 337 patients across different surgical procedures were included.
The aggregated effect of intraoperative methadone on postoperative opioid consumption did not reveal a significant effect, WMD (95% CI) of −0.51 (−1.79 to 0.76), (P=0.43) IV morphine equivalents.
In contrast, the effect of methadone on postoperative pain demonstrated a significant effect in the postanesthesia care unit, WMD (95% CI) of −1.11 (−1.88 to −0.33), P=0.005, and at 24 hours, WMD (95% CI) of −1.35 (−2.03 to −0.67), P<0.001.
Conclusions.
The use of intraoperative methadone reduces postoperative pain when compared to morphine.
In addition, the beneficial effect of methadone on postoperative pain is not attributable to an increase in postsurgical opioid consumption.
Our results suggest that intraoperative methadone may be a viable strategy to reduce acute pain in surgical patients.
American Psychological Association (APA)
Kendall, Mark C.& Alves, Lucas J.& Pence, Kristi& Mukhdomi, Taif& Croxford, Daniel& De Oliveira, Gildasio S.. 2020. The Effect of Intraoperative Methadone Compared to Morphine on Postsurgical Pain: A Meta-Analysis of Randomized Controlled Trials. Anesthesiology Research and Practice،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1130548
Modern Language Association (MLA)
Kendall, Mark C.…[et al.]. The Effect of Intraoperative Methadone Compared to Morphine on Postsurgical Pain: A Meta-Analysis of Randomized Controlled Trials. Anesthesiology Research and Practice No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1130548
American Medical Association (AMA)
Kendall, Mark C.& Alves, Lucas J.& Pence, Kristi& Mukhdomi, Taif& Croxford, Daniel& De Oliveira, Gildasio S.. The Effect of Intraoperative Methadone Compared to Morphine on Postsurgical Pain: A Meta-Analysis of Randomized Controlled Trials. Anesthesiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1130548
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130548