CK20 and CK56 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective
Joint Authors
Akhtar, Mohammed
Rashid, Sameera
Gashir, Mohamed Ben
Taha, Noheir Mostafa
Al Bozom, Issam
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cytokeratins belong to the family of intermediate filaments.
They are expressed in a highly specific manner in epithelial cells where they play a crucial role in the integrity and mechanical stability of the cells.
Several types of cytokeratins have been described in normal as well as neoplastic urothelium.
In the case of urothelial neoplasms expression of CK20 and CK5/6 has been shown in several studies to have diagnostic and prognostic implications.
Thus, low-grade urothelial carcinoma manifests CK expression limited to the umbrella cells, while high-grade tumors usually have an expression in the entire thickness of the urothelium except for the basal layer.
CK5/6 expression on the other hand is expressed in the basal cells in all low-grade and some high-grade urothelial carcinomas.
Diffuse CK20 staining accompanied by loss of CK5/6-positive basal layer is usually associated with aggressive clinical behavior.
Double staining of the slides for these cytokeratins may facilitate proper interpretation and correlation.
American Psychological Association (APA)
Akhtar, Mohammed& Rashid, Sameera& Gashir, Mohamed Ben& Taha, Noheir Mostafa& Al Bozom, Issam. 2020. CK20 and CK56 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective. Advances in Urology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1130643
Modern Language Association (MLA)
Akhtar, Mohammed…[et al.]. CK20 and CK56 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective. Advances in Urology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1130643
American Medical Association (AMA)
Akhtar, Mohammed& Rashid, Sameera& Gashir, Mohamed Ben& Taha, Noheir Mostafa& Al Bozom, Issam. CK20 and CK56 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective. Advances in Urology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1130643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130643