Mathematical Analysis and Clinical Implications of an HIV Model with Adaptive Immunity
Joint Authors
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-16
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
In this paper, a mathematical model describing the human immunodeficiency virus (HIV) pathogenesis with adaptive immune response is presented and studied.
The mathematical model includes six nonlinear differential equations describing the interaction between the uninfected cells, the exposed cells, the actively infected cells, the free viruses, and the adaptive immune response.
The considered adaptive immunity will be represented by cytotoxic T-lymphocytes cells (CTLs) and antibodies.
First, the global stability of the disease-free steady state and the endemic steady states is established depending on the basic reproduction number R0, the CTL immune response reproduction number R1z, the antibody immune response reproduction number R1w, the antibody immune competition reproduction number R2w, and the CTL immune response competition reproduction number R3z.
On the other hand, different numerical simulations are performed in order to confirm numerically the stability for each steady state.
Moreover, a comparison with some clinical data is conducted and analyzed.
Finally, a sensitivity analysis for R0 is performed in order to check the impact of different input parameters.
American Psychological Association (APA)
Danane, Jaouad& Allali, Karam. 2019. Mathematical Analysis and Clinical Implications of an HIV Model with Adaptive Immunity. Computational and Mathematical Methods in Medicine،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1130710
Modern Language Association (MLA)
Danane, Jaouad& Allali, Karam. Mathematical Analysis and Clinical Implications of an HIV Model with Adaptive Immunity. Computational and Mathematical Methods in Medicine No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1130710
American Medical Association (AMA)
Danane, Jaouad& Allali, Karam. Mathematical Analysis and Clinical Implications of an HIV Model with Adaptive Immunity. Computational and Mathematical Methods in Medicine. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1130710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130710