Antimicrobial Activity and DNABSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethaneethene as Bridging Ligands
Joint Authors
Glišić, Biljana Đ.
Đurić, Sonja Ž.
Vojnovic, Sandra
Andrejević, Tina P.
Stevanović, Nevena Lj
Savić, Nada D.
Nikodinovic-Runic, Jasmina
Djuran, Miloš I.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
1,2-Bis(4-pyridyl)ethane (bpa) and 1,2-bis(4-pyridyl)ethene (bpe) were used for the synthesis of polynuclear silver(I) complexes, {[Ag(bpa)]NO3}n (1), {[Ag(bpa)2]CF3SO3.H2O}n (2) and {[Ag(bpe)]CF3SO3}n (3).
In complexes 1–3, the corresponding nitrogen-containing heterocycle acts as a bridging ligand between two Ag(I) ions.
In vitro antimicrobial activity of these complexes, along with the ligands used for their synthesis, was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and fungi.
The silver(I) complexes 1–3 showed selectivity towards Candida spp.
and Gram-negative Escherichia coli in comparison to the other investigated bacterial strains, effectively inhibiting the growth of four different Candida species with minimal inhibitory concentrations (MICs) between 2.5 and 25 μg/mL and the growth of E.
coli, with MIC value being 12.5 μg/mL.
Importantly, complex 2 significantly reduced C.
albicans filamentation, an essential process for its pathogenesis.
Antiproliferative effect on the normal human lung fibroblast cell line MRC-5 was also evaluated with the aim of determining the therapeutic potential of the complexes 1–3.
The interactions of these complexes with calf thymus DNA (ctDNA) and bovine serum albumin (BSA) were studied to evaluate their binding activities towards these biomolecules for possible insights on their mode of action.
American Psychological Association (APA)
Đurić, Sonja Ž.& Vojnovic, Sandra& Andrejević, Tina P.& Stevanović, Nevena Lj& Savić, Nada D.& Nikodinovic-Runic, Jasmina…[et al.]. 2020. Antimicrobial Activity and DNABSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethaneethene as Bridging Ligands. Bioinorganic Chemistry and Applications،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1130720
Modern Language Association (MLA)
Đurić, Sonja Ž.…[et al.]. Antimicrobial Activity and DNABSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethaneethene as Bridging Ligands. Bioinorganic Chemistry and Applications No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1130720
American Medical Association (AMA)
Đurić, Sonja Ž.& Vojnovic, Sandra& Andrejević, Tina P.& Stevanović, Nevena Lj& Savić, Nada D.& Nikodinovic-Runic, Jasmina…[et al.]. Antimicrobial Activity and DNABSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethaneethene as Bridging Ligands. Bioinorganic Chemistry and Applications. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1130720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130720