Novel Gallium(III), Germanium(IV), and Hafnium(IV) Folate Complexes and Their Spectroscopic, Thermal Decomposition, Morphological, and Biological Characteristics
Author
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In this study, we describe novel gallium(III), germanium(IV), and hafnium(IV) folate complexes, including their synthesis and analyses.
The synthesized folate complexes were also subject to thermal analysis (TGA) to better examine their thermal degradation and kinetic properties.
The folate complexes had high stability and were nonspontaneous.
The Coats–Redfern and Horowitz–Metzger equations were used to determine thermodynamic parameters and describe the kinetic properties.
These complexes were synthesized through the chemical interactions in neutralized media between the folic acid drug ligand (FAH2) with GaCl3, GeCl4, and HfCl4 metal salts at 1 : 2 (metal : ligand) molar ratio.
The conductance measurements have low values due to their nonelectrolytic behavior.
The X-ray powder diffraction solid powder pattern revealed a semicrystalline nature.
In vitro, we screened the synthesized folate chelates for antibacterial and antifungal activities.
The inhibition of four bacterial and two fungi pathogens (E.
coli, B.
subtilis, P.
aeruginosa, S.
aureus, A.
flavus, and Candida albicans) was improved using a folic acid drug relative to the control drug.
American Psychological Association (APA)
El-Habeeb, Abeer A.. 2020. Novel Gallium(III), Germanium(IV), and Hafnium(IV) Folate Complexes and Their Spectroscopic, Thermal Decomposition, Morphological, and Biological Characteristics. Bioinorganic Chemistry and Applications،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1130727
Modern Language Association (MLA)
El-Habeeb, Abeer A.. Novel Gallium(III), Germanium(IV), and Hafnium(IV) Folate Complexes and Their Spectroscopic, Thermal Decomposition, Morphological, and Biological Characteristics. Bioinorganic Chemistry and Applications No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1130727
American Medical Association (AMA)
El-Habeeb, Abeer A.. Novel Gallium(III), Germanium(IV), and Hafnium(IV) Folate Complexes and Their Spectroscopic, Thermal Decomposition, Morphological, and Biological Characteristics. Bioinorganic Chemistry and Applications. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1130727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130727