Synthesis of Amino Acid Schiff Base Nickel (II) Complexes as Potential Anticancer Drugs In Vitro
Joint Authors
Hu, Ping
Zhao, Peiran
Dong, Jianfang
Yang, Dawei
Gao, Lei
Li, Lianzhi
Li, Yang
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Three hexacoordinated octahedral nickel (II) complexes, [Ni (Trp-sal) (phen) (CH3OH)] (1), [Ni (Trp-o-van) (phen) (CH3OH)]•2CH3OH (2), and [Ni (Trp-naph) (phen) (CH3OH)] (3) (where Trp-sal = Schiff base derived from tryptophan and salicylaldehyde, Trp-o-van = Schiff base derived from tryptophan and o-vanillin, Trp-naph = Schiff base derived from tryptophan and 2-hydroxy-1-naphthaldehyde, phen = 1, 10-phenanthroline), have been synthesized and characterized as potential anticancer agents.
Details of structural study of these complexes using single-crystal X-ray crystallography showed that distorted octahedral environment around nickel (II) ion has been satisfied by three nitrogen atoms and three oxygen atoms.
All these complexes displayed moderate cytotoxicity toward esophageal cancer cell line Eca-109 with the IC50 values of 23.95 ± 2.54 μM for 1, 18.14 ± 2.39 μM for 2, and 21.89 ± 3.19 μM for 3.
Antitumor mechanism studies showed that complex 2 can increase the autophagy, reactive oxygen species (ROS) levels, and decrease the mitochondrial membrane potential remarkably in a dose-dependent manner in the Eca-109 cells.
Complex 2 can cause cell cycle arrest in the G2/M phase.
Additionally, complex 2 can regulate the Bcl-2 family and autophagy-related proteins.
American Psychological Association (APA)
Li, Yang& Dong, Jianfang& Zhao, Peiran& Hu, Ping& Yang, Dawei& Gao, Lei…[et al.]. 2020. Synthesis of Amino Acid Schiff Base Nickel (II) Complexes as Potential Anticancer Drugs In Vitro. Bioinorganic Chemistry and Applications،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1130738
Modern Language Association (MLA)
Li, Yang…[et al.]. Synthesis of Amino Acid Schiff Base Nickel (II) Complexes as Potential Anticancer Drugs In Vitro. Bioinorganic Chemistry and Applications No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1130738
American Medical Association (AMA)
Li, Yang& Dong, Jianfang& Zhao, Peiran& Hu, Ping& Yang, Dawei& Gao, Lei…[et al.]. Synthesis of Amino Acid Schiff Base Nickel (II) Complexes as Potential Anticancer Drugs In Vitro. Bioinorganic Chemistry and Applications. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1130738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130738