A Pilot Study of Parameter-Optimized Low-Intensity Pulsed Ultrasound Stimulation for the Bone Marrow Mesenchymal Stem Cells Viability Improvement
Joint Authors
Yin, Wuliang
Yang, Xiuzhi
Wu, Yu
Li, Jiqing
An, Yang
Wang, Yanfen
Wang, Man
Wu, Qiuli
Qu, Zhigang
Ning, Guangzhi
Feng, Shiqing
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
To investigate how a back propagation neural network based on genetic algorithm (GA-BPNN) optimizes the low-intensity pulsed ultrasound (LIPUS) stimulation parameters to improve the bone marrow mesenchymal stem cells (BMSCs) viability further.
The LIPUS parameters were set at various frequencies (0.6, 0.8, 1.0, and 1.2 MHz), voltages (5, 6, 7, and 8 V), and stimulation durations (3, 6, and 9 minutes).
As only some discrete points can be set up in the experiments, the optimal LIPUS stimulation parameter may not be in the value of these settings.
The GA-BPNN algorithm is used to optimize parameters of LIPUS to increase the BMSCs viability further.
The BMSCs viability of the LIPUS-treated group was improved up to 19.57% (P<0.01).
With the optimization via the GA-BPNN algorithm, the viability of BMSCs was further improved by about 5.36% (P<0.01) under the optimized condition of 6.92 V, 1.02 MHz, and 7.3 min.
LIPUS is able to improve the BMSCs viability, which can be improved further by LIPUS with parameter optimization via GA-BPNN algorithm.
American Psychological Association (APA)
Yang, Xiuzhi& Wu, Yu& Li, Jiqing& Yin, Wuliang& An, Yang& Wang, Yanfen…[et al.]. 2019. A Pilot Study of Parameter-Optimized Low-Intensity Pulsed Ultrasound Stimulation for the Bone Marrow Mesenchymal Stem Cells Viability Improvement. Computational and Mathematical Methods in Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1130740
Modern Language Association (MLA)
Yang, Xiuzhi…[et al.]. A Pilot Study of Parameter-Optimized Low-Intensity Pulsed Ultrasound Stimulation for the Bone Marrow Mesenchymal Stem Cells Viability Improvement. Computational and Mathematical Methods in Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1130740
American Medical Association (AMA)
Yang, Xiuzhi& Wu, Yu& Li, Jiqing& Yin, Wuliang& An, Yang& Wang, Yanfen…[et al.]. A Pilot Study of Parameter-Optimized Low-Intensity Pulsed Ultrasound Stimulation for the Bone Marrow Mesenchymal Stem Cells Viability Improvement. Computational and Mathematical Methods in Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1130740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130740