Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives
Joint Authors
Xun-Zhong, Zou
An-Sheng, Feng
Fu-Ran, Zeng
Min-Cheng, Lai
Yan-Zhi, Liao
Meng, Mei
Yu, Li
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Two pyridine thiazole derivatives, namely, 4-(pyridin-2-yl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)thiazole (L1) and 4-(pyridin-3-yl)-2-(2-(pyridin-4-ylmethylene)hydrazinyl)thiazole (L2), were afforded by a cyclization reaction between α-haloketone and thioamide, and their Zn(II) complexes were prepared by the reaction of ligands and corresponding metal salts, respectively, and characterized by X-ray diffraction and elemental analysis.
Both crystals were obtained by ether diffusion and crystallized in a monoclinic system.
The in vitro antimicrobial activity of the Zn(II) complexes and ligands was screened using the microplate reader method, and in vitro antitumor activities of the complexes were evaluated by MTT, with a view to developing new improved bioactive materials with novel properties.
The biological activity studies of the compounds showed that the metal complexes were more active than the free ligands, and some compounds had absolute specificity for certain bacteria or cancer cell lines.
American Psychological Association (APA)
Xun-Zhong, Zou& An-Sheng, Feng& Fu-Ran, Zeng& Min-Cheng, Lai& Yan-Zhi, Liao& Meng, Mei…[et al.]. 2020. Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives. Bioinorganic Chemistry and Applications،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1130741
Modern Language Association (MLA)
Xun-Zhong, Zou…[et al.]. Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives. Bioinorganic Chemistry and Applications No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1130741
American Medical Association (AMA)
Xun-Zhong, Zou& An-Sheng, Feng& Fu-Ran, Zeng& Min-Cheng, Lai& Yan-Zhi, Liao& Meng, Mei…[et al.]. Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives. Bioinorganic Chemistry and Applications. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1130741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130741