Integrative Deep Learning for Identifying Differentially Expressed (DE) Biomarkers
Joint Authors
Lim, Jayeon
Bang, SoYoun
Kim, Jiyeon
Park, Cheolyong
Cho, JunSang
Kim, SungHwan
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
As a large amount of genetic data are accumulated, an effective analytical method and a significant interpretation are required.
Recently, various methods of machine learning have emerged to process genetic data.
In addition, machine learning analysis tools using statistical models have been proposed.
In this study, we propose adding an integrated layer to the deep learning structure, which would enable the effective analysis of genetic data and the discovery of significant biomarkers of diseases.
We conducted a simulation study in order to compare the proposed method with metalogistic regression and meta-SVM methods.
The objective function with lasso penalty is used for parameter estimation, and the Youden J index is used for model comparison.
The simulation results indicate that the proposed method is more robust for the variance of the data than metalogistic regression and meta-SVM methods.
We also conducted real data (breast cancer data (TCGA)) analysis.
Based on the results of gene set enrichment analysis, we obtained that TCGA multiple omics data involve significantly enriched pathways which contain information related to breast cancer.
Therefore, it is expected that the proposed method will be helpful to discover biomarkers.
American Psychological Association (APA)
Lim, Jayeon& Bang, SoYoun& Kim, Jiyeon& Park, Cheolyong& Cho, JunSang& Kim, SungHwan. 2019. Integrative Deep Learning for Identifying Differentially Expressed (DE) Biomarkers. Computational and Mathematical Methods in Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130745
Modern Language Association (MLA)
Lim, Jayeon…[et al.]. Integrative Deep Learning for Identifying Differentially Expressed (DE) Biomarkers. Computational and Mathematical Methods in Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1130745
American Medical Association (AMA)
Lim, Jayeon& Bang, SoYoun& Kim, Jiyeon& Park, Cheolyong& Cho, JunSang& Kim, SungHwan. Integrative Deep Learning for Identifying Differentially Expressed (DE) Biomarkers. Computational and Mathematical Methods in Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1130745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130745