Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway
Joint Authors
Li, Chengpeng
Deng, Yuanyuan
Chen, Jincan
Miao, Tifang
Cai, Xianhong
Henri, Justin
Chen, Lanmei
Wang, Tao
Wang, Jie
Liu, Ying
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-17
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Two new Ru(II) complexes containing O, O-chelated ligands, Ru(dip)2(SA) (Ru-1) and Ru(dmp)2(SA) (Ru-2) (dip = 4,7-diphenyl-1,10-phenanthroline; dmp = 2,9-dimethyl-1,10-phenanthroline; SA = salicylate) were synthesized to evaluate their cytotoxicity in vitro.
These complexes were found to exhibit moderate antitumor activity to different types of human cancers, including A549 (human lung carcinoma), MCF-7 (breast cancer), HeLa (human cervical cancer), and HepG2 (human hepatocellular carcinoma) cell lines, but displayed low toxicity to human normal cell lines BEAS-2B (immortalized human bronchial epithelial cells) when compared with that of cisplatin.
Further studies revealed that these complexes could induce apoptosis in A549 cells, including activating caspase family proteins and poly (ADP-ribose) polymerase (PARP), reducing Bcl-2/Bax and Bcl-xl/Bad ratio, enhancing cellular reactive oxygen species (ROS) accumulation, triggering DNA damage, decreasing mitochondrial membrane potential (MMP), and leading cytochrome c release from mitochondria.
Notably, complex Ru-1 showed low toxicity to developing zebrafish embryos.
The obtained results suggest that these new synthetic complexes have the potential to be developed as low-toxicity agents for lung cancer treatment.
American Psychological Association (APA)
Chen, Jincan& Wang, Jie& Deng, Yuanyuan& Wang, Tao& Miao, Tifang& Li, Chengpeng…[et al.]. 2020. Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway. Bioinorganic Chemistry and Applications،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1130752
Modern Language Association (MLA)
Chen, Jincan…[et al.]. Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway. Bioinorganic Chemistry and Applications No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1130752
American Medical Association (AMA)
Chen, Jincan& Wang, Jie& Deng, Yuanyuan& Wang, Tao& Miao, Tifang& Li, Chengpeng…[et al.]. Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway. Bioinorganic Chemistry and Applications. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1130752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130752