Multiple-Strain Malaria Infection and Its Impacts on Plasmodium falciparum Resistance to Antimalarial Therapy: A Mathematical Modelling Perspective
Joint Authors
Luboobi, Livingstone
Orwa, Titus Okello
Mbogo, Rachel Waema
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-26, 26 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-11
Country of Publication
Egypt
No. of Pages
26
Main Subjects
Abstract EN
The emergence of parasite resistance to antimalarial drugs has contributed significantly to global human mortality and morbidity due to malaria infection.
The impacts of multiple-strain malarial parasite infection have further generated a lot of scientific interest.
In this paper, we demonstrate, using the epidemiological model, the effects of parasite resistance and competition between the strains on the dynamics and control of Plasmodium falciparum malaria.
The analysed model has a trivial equilibrium point which is locally asymptotically stable when the parasite’s effective reproduction number is less than unity.
Using contour plots, we observed that the efficacy of antimalarial drugs used, the rate of development of resistance, and the rate of infection by merozoites are the most important parameters in the multiple-strain P.
falciparum infection and control model.
Although the drug-resistant strain is shown to be less fit, the presence of both strains in the human host has a huge impact on the cost and success of antimalarial treatment.
To reduce the emergence of resistant strains, it is vital that only effective antimalarial drugs are administered to patients in hospitals, especially in malaria-endemic regions.
Our results emphasize the call for regular and strict surveillance on the use and distribution of antimalarial drugs in health facilities in malaria-endemic countries.
American Psychological Association (APA)
Orwa, Titus Okello& Mbogo, Rachel Waema& Luboobi, Livingstone. 2019. Multiple-Strain Malaria Infection and Its Impacts on Plasmodium falciparum Resistance to Antimalarial Therapy: A Mathematical Modelling Perspective. Computational and Mathematical Methods in Medicine،Vol. 2019, no. 2019, pp.1-26.
https://search.emarefa.net/detail/BIM-1130786
Modern Language Association (MLA)
Orwa, Titus Okello…[et al.]. Multiple-Strain Malaria Infection and Its Impacts on Plasmodium falciparum Resistance to Antimalarial Therapy: A Mathematical Modelling Perspective. Computational and Mathematical Methods in Medicine No. 2019 (2019), pp.1-26.
https://search.emarefa.net/detail/BIM-1130786
American Medical Association (AMA)
Orwa, Titus Okello& Mbogo, Rachel Waema& Luboobi, Livingstone. Multiple-Strain Malaria Infection and Its Impacts on Plasmodium falciparum Resistance to Antimalarial Therapy: A Mathematical Modelling Perspective. Computational and Mathematical Methods in Medicine. 2019. Vol. 2019, no. 2019, pp.1-26.
https://search.emarefa.net/detail/BIM-1130786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130786